Radiation therapy is a major tool in the management of this family of cancers. This issue of Radiation Medicine Rounds includes reviews of all major recent advances in treatment of breast cancer. Articles also review current knowledge in the areas of biologic agents, Intensity Modulated Radiation Therapy, Image-Guided Brachytherapy, and robotic surgery in gynecologic cancer. Breast Cancer will provide the practitioner with a full current overview of the present best practices and recent research in management of this complex and challenging family of cancers.