Antibiotics Challenges, Mechanisms, Opportunities

Image of the book cover for 'Antibiotics'
Author: Christopher Walsh, Timothy Wencewicz
Affiliation: Harvard Medical School, Boston, USA
Publisher: Wiley-Blackwell
Publication Date: 2016
ISBN 10: 1555819303
ISBN 13: 9781555819309
eISBN: 9781555819316
Edition: 2nd
Description:
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.
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