ROOK'S TEXTBOOK OF DERMATOLOGY, 4 VOLUME SET

Author: Christopher Griffiths, MD, FRCP, FMedSci, Jonathan Barker, MD, FRCP, FRCPath, Tanya Bleiker, FRCP, Robert Chalmers, FRCP, Daniel Creamer, MD, FRCP
Affiliation: Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
Publisher: Wiley-Blackwell
Publication Date: 2016
ISBN 10: 1118441192
ISBN 13: 9781118441190
Edition: 9th

Description:

Rook’s Textbook of Dermatology, Ninth Edition provides you with: • The very best content from the number one brand in dermatology – an essential consultation tool for all dermatologists • An outstanding combined digital/print resource, exhaustively covering every dermatological disorder • A complete overhaul of its content – each disorder now follows a consistent templated approach • A fresh approach to the classification of disorders and organization of chapters, of which there are now 160 instead of 80, all organised into 14 logical sections • A newly designed sophisticated online platform with a fast and powerful digital search functionality – search by keyword, disorder or chapter or consult the online image database and get expert clinical advice more quickly than ever • Lavishly illustrated chapters with over 5000 colour images showing variation in disease patterns by body location, skin type and severity

Table of Contents

Front Matter

  • ABOUT
  • preface
  • Associate Editors
  • Contributors
  • Preface to the Ninth Edition
  • Preface to the First Edition

Part 1 Foundations of Dermatology

    CHAPTER 1: History of Dermatology

    • Overview
    • Introduction: when did dermatology history begin?
    • Ancient dermatology writings
    • Growth of rational medicine
    • Dermatology after the fall of Rome
    • Growth of scientific dermatology
    • Development of dermatology as a world specialty in the 20th century
    • References

    CHAPTER 2: Structure and Function of the Skin

    • Overview
    • Components of normal human skin
    • Skin development
    • Epidermal and adnexal structures
    • Keratinocytes
    • Eccrine and apocrine glands
    • Pilosebaceous unit
    • Nails
    • Merkel cells
    • Innate immunity
    • Skin microbiome
    • Langerhans cells
    • Immune surveillance
    • Mast cells
    • Melanocytes
    • Desmosomes
    • Adherens junctions
    • Gap junctions
    • Tight junctions
    • Dermal–epidermal basement membrane
    • Basement membrane collagen
    • Laminins
    • Hemidesmosomes
    • Anchoring fibrils
    • Extracellular matrix
    • Collagens
    • Collagen biosynthesis
    • Collagen biology
    • Collagen cross-linking
    • Collagen degradation
    • Elastic fibres
    • Elastin
    • Elastin-associated microfibrils
    • Proteoglycan/glycosaminoglycans
    • Fibroblasts
    • Blood vessels and lymphatics
    • Subcutaneous fat
    • Physiological functions of skin
    • Skin homeostasis
    • Skin ageing
    • References

    CHAPTER 3: Histopathology of the Skin: General Principles

    • Overview
    • Introduction
    • Biopsy of the skin
    • Laboratory methods
    • Immunopathology
    • Other diagnostic methods
    • Artefacts
    • Approach to microscopic examination of tissue sections
    • Conclusions
    • References

    CHAPTER 4: Diagnosis of Skin Disease

    • Overview
    • Fundamentals of diagnosis
    • Disease definition
    • The history
    • Quality of life in dermatology patients
    • Examination of the skin
    • Description of skin lesions
    • Clinical microscopy, dermoscopy and other imaging systems
    • Fine-needle aspiration of lymph nodes
    • Radiological and imaging examinations
    • Skin testing (prick and scratch, intradermal and patch testing) [1]
    • Teledermatology
    • Mobile smartphone applications
    • References

    CHAPTER 5: Epidemiology of Skin Disease

    • Overview
    • What is epidemiology and why is it relevant to dermatology?
    • Thinking in terms of populations rather than individuals
    • How much of a public health problem is skin disease?
    • What determines the frequency of skin disease in populations?
    • Describing the natural history and associations of specific skin diseases
    • Health services research in dermatology
    • Conclusions
    • Glossary of epidemiological terms
    • Checklist for reading ‘epidemiological studies’ in dermatology
    • Recommended further reading and useful dermatoepidemiology resources
    • References

    CHAPTER 6: Health Economics and Skin Disease

    • Overview
    • Background
    • Introduction to methods and approaches in health economics
    • Economic burden of disease in dermatology
    • Critical reflection of studies on disease burden
    • Impact for decision making in dermatology practice
    • References

    CHAPTER 7: Genetics and the Skin

    • Overview
    • Advances in genetics
    • Nosology and principles of medical genetics
    • Mutations and disease
    • Mosaicism, Lyonization and the lines of Blaschko
    • Genome sequence and analysis of inherited disorders
    • Prenatal diagnosis
    • References

    CHAPTER 8: Inflammation, Immunology and Allergy

    • Overview
    • Clinical characteristics of inflammation
    • Phases of inflammation
    • Cellular components of cutaneous inflammation
    • Innate immune defence mechanisms
    • Cells regulating innate immunity
    • Adaptive immune system
    • Mediators of inflammation
    • Allergy
    • References

    CHAPTER 9: Photobiology

    • Overview
    • Basic principles
    • Normal effects of UVR on skin
    • Photoprotection
    • Population exposure to UVR
    • References

    CHAPTER 10: Cutaneous Response to Injury and Wound Healing

    • Overview
    • Introduction
    • Inflammation and the immune response
    • Re-epithelialization
    • Angiogenesis
    • Fibroblast recruitment, matrix synthesis and scarring
    • Abnormal wound healing and scarring
    • Age-related changes in wound healing
    • Physiological basis of treatment of wounds
    • Novel therapies for wound healing
    • References

    CHAPTER 11: Psychological and Social Impact of Long-term Dermatological Conditions

    • Overview
    • Psychological and social challenges of dermatological conditions
    • Psychological impact of dermatological conditions with emphasis on psoriasis
    • Social impact of dermatology conditions
    • Skin conditions and associated co-morbidities
    • Treatment challenges
    • Implications of psychological and social impact of dermatological conditions for integrated clinical management
    • References

    CHAPTER 12: Adverse Immunological Reactions to Drugs

    • Overview
    • Introduction
    • IgE-mediated drug hypersensitivity
    • T-cell-mediated drug hypersensitivity
    • Drugs as haptens
    • Drugs as pro-haptens
    • Drugs as non-haptens
    • Understanding the clinical phenotype
    • References

    CHAPTER 13: Topical Drug Delivery

    • Overview
    • Introduction: skin barrier function
    • Penetration pathways: mechanisms of percutaneous absorption
    • Factors determining drug permeation into the skin
    • Topical drug formulations used to treat dermatological disease
    • Assessment of topical drug bioavailability and bioequivalence between formulations
    • Optimization of dermatological medicines
    • Conclusions
    • References

    CHAPTER 14: Clinical Pharmacology

    • Overview
    • Introduction
    • Types of drugs and terminology
    • Pharmacokinetics
    • Pharmacodynamics
    • Factors that affect therapeutic outcome
    • Drug development and licensing procedures
    • Resources
    • References

Part 2 Management

    CHAPTER 15: Principles of Holistic Management of Skin Disease

    • Overview
    • What is holistic management and is it important?
    • Are we doctors or disease management technicians?
    • Is dermatology different?
    • How important is it to empower patients?
    • Conclusions
    • References

    CHAPTER 16: Principles of Measurement and Assessment in Dermatology

    • Overview
    • Measurement of skin disease severity
    • Assessment tools
    • Objective methods for measuring skin properties
    • Measurement of the impact of skin disease
    • Quality of life measures used in dermatology
    • References

    CHAPTER 17: Principles of Evidence-based Dermatology

    • Overview
    • Evidence-based medicine
    • Formulating questions and finding evidence
    • Critically appraising evidence and applying it to individual patients
    • Evaluating the data in clinical research papers and a shortcut method for reading clinical research papers
    • References

    CHAPTER 18: Principles of Topical Therapy

    • Overview
    • Introduction
    • Prescribing topical treatment
    • Hazards associated with topical treatment
    • Formulation of topical medicaments
    • Topical treatments used in the management of skin disease
    • References

    CHAPTER 19: Principles of Systemic Therapy

    • Overview
    • Introduction
    • Immunomodulatory drugs
    • Antimicrobial drugs
    • References

    CHAPTER 20: Principles of Skin Surgery

    • Overview
    • Introduction
    • Critical anatomical considerations
    • Equipment and sterilization
    • Safety aspects
    • Complications
    • Local anaesthetics
    • Biopsy techniques
    • Preoperative preparation
    • Simple excision, suture technique and wound closure
    • Dressings and postoperative care
    • Flaps (Figures 20.27, 20.28, 20.29, 20.30 and 20.31)
    • Skin grafts
    • Other techniques for facilitating closure
    • Mohs micrographic surgery
    • Electrocautery and electrosurgery [1,2,3]
    • Cryosurgery
    • Caustics
    • Intralesional corticosteroid therapy [1]
    • Intralesional therapies for skin malignancies
    • Miscellaneous surgical procedures and techniques
    • Management of specific conditions
    • References

    CHAPTER 21: Principles of Phototherapy

    • Overview
    • Introduction
    • History and background
    • Ultraviolet radiation
    • Indications for phototherapy
    • How different therapies are administered
    • Adverse effects
    • Patient selection, assessment and education
    • Patient and staff safety
    • Patient follow-up: skin cancer surveillance
    • Clinical governance
    • How to set up a phototherapy unit
    • What’s new: developments
    • References

    CHAPTER 22: Principles of Photodynamic Therapy

    • Overview
    • What is photodynamic therapy?
    • History and background
    • Photosensitizers used for photodynamic therapy in dermatology
    • Light sources
    • Indications
    • Contraindications
    • Methodology and regimens
    • Adverse effects
    • Clinical governance
    • What’s new?
    • References

    CHAPTER 23: Principles of Cutaneous Laser Therapy

    • Overview
    • Introduction
    • Light and laser light characteristics
    • Clinical applications of lasers and flashlamps
    • References

    CHAPTER 24: Principles of Radiotherapy

    • Overview
    • Introduction
    • Ionizing radiation in the treatment of skin cancer
    • Superficial radiotherapy treatment technique
    • Megavoltage X-ray therapy technique
    • Radiosensitivity
    • Indications for radiotherapy
    • Acute radiation reaction (acute radiodermatitis) (Figures 24.18a–c and 24.19a–c)
    • Late radiation reaction (chronic radiodermatitis) (Figures 24.20 and 24.21)
    • Tumour recurrence after radiotherapy
    • Radiation-induced tumours
    • Rare tumours associated with previous irradiation
    • References

Part 3 Infections and Infestations

    CHAPTER 25: Viral Infections

    • Overview
    • Introduction
    • POXVIRUS INFECTIONS
    • HERPESVIRUS INFECTIONS
    • POLYOMAVIRUS INFECTIONS
    • HUMAN PAPILLOMAVIRUS INFECTIONS
    • HEPATITIS INFECTIONS
    • PARVOVIRUS INFECTIONS
    • HUMAN RETROVIRUS INFECTION
    • VIRAL INSECT-BORNE AND HAEMORRHAGIC FEVERS
    • OTHER CUTANEOUS PROBLEMS ASSOCIATED WITH VIRAL INFECTIONS
    • References

    CHAPTER 26: Bacterial Infections

    • Overview
    • Introduction: normal skin bacteria and bacterial microbiome
    • GRAM-POSITIVE BACTERIA
    • GRAM-NEGATIVE BACTERIA
    • ANAEROBIC BACTERIA
    • SPIROCHAETES AND SPIRAL BACTERIA
    • LEGIONELLOSIS
    • MISCELLANEOUS
    • MYCOPLASMA INFECTIONS
    • CHLAMYDIAE [1,2]
    • RICKETTSIAL INFECTIONS
    • ACTINOMYCETE INFECTIONS
    • DERMATOSES POSSIBLY ATTRIBUTABLE TO BACTERIA
    • References

    CHAPTER 27: Mycobacterial Infections

    • Overview
    • Introduction
    • MYCOBACTERIAL INFECTION
    • TUBERCULOSIS OF THE SKIN
    • TUBERCULIDS
    • NON-TUBERCULOUS (ATYPICAL) MYCOBACTERIA
    • References

    CHAPTER 28: Leprosy

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations [99]
    • Management
    • Resources
    • References

    CHAPTER 29: Syphilis and Congenital Syphilis

    • Overview
    • Syphilis
    • Syphilis, congenital
    • References

    CHAPTER 30: Other Sexually Transmitted Bacterial Diseases

    • Overview
    • Gonorrhoea
    • Chlamydia infection, genital
    • Lymphogranuloma venereum (ulcerative genital Chlamydia trachomatis infection)
    • Chancroid (Haemophilus ducreyi infection)
    • Granuloma inguinale (donovanosis)
    • References

    CHAPTER 31: HIV and the Skin

    • Overview
    • HIV INFECTION AND AIDS
    • DERMATOLOGICAL MANIFESTATIONS OF HIV INFECTION
    • References

    CHAPTER 32: Fungal Infections

    • Overview
    • Introduction
    • Basic biology
    • SUPERFICIAL MYCOSES
    • SUBCUTANEOUS MYCOSES
    • SYSTEMIC MYCOSES
    • References

    CHAPTER 33: Parasitic Diseases

    • Overview
    • INFECTION WITH HUMAN NEMATODES
    • INFECTION WITH NEMATODES OF OTHER ANIMALS
    • INFECTION WITH TREMATODES
    • INFECTION WITH CESTODES
    • INFECTION WITH PROTOZOA
    • References

    CHAPTER 34: Arthropods

    • Overview
    • SKIN DISEASE DUE TO ARTHROPODS
    • CLASS INSECTA
    • CLASS ARACHNIDA
    • CLASS CHILOPODA (CENTIPEDES) AND DIPLOPODA (MILLIPEDES)
    • References

Part 4 Inflammatory Dermatoses

    CHAPTER 35: Psoriasis and Related Disorders

    • Overview
    • Definition
    • PSORIASIS, PLAQUE
    • PUSTULAR PSORIASIS
    • PSORIATIC ARTHRITIS
    • References

    CHAPTER 36: Pityriasis Rubra Pilaris

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Resources
    • References

    CHAPTER 37: Lichen Planus and Lichenoid Disorders

    • Overview
    • Definition
    • LICHEN PLANUS
    • LICHEN STRIATUS
    • References

    CHAPTER 38: Graft-versus-host Disease

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Graft-versus-host disease, acute
    • Graft-versus-host disease, chronic
    • Resources
    • References

    CHAPTER 39: Eczematous Disorders

    • Overview
    • ASSESSMENT, INVESTIGATION AND MANAGEMENT OF ECZEMATOUS DISORDERS
    • MISCELLANEOUS SPECIFIED ECZEMATOUS DERMATOSES
    • OTHER RELATED DERMATOSES
    • References

    CHAPTER 40: Seborrhoeic Dermatitis

    • Overview
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • References

    CHAPTER 41: Atopic eczema (atopic dermatitis)

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management [1,2,3]
    • Treatment (Figure 41.24)
    • Conclusion
    • References

    CHAPTER 42: Urticaria

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations (Box 42.7)
    • Management (Figure 42.12)
    • References

    CHAPTER 43: Recurrent Angio-oedema without Weals

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Resources
    • References

    CHAPTER 44: Urticarial Vasculitis

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations (Table 44.1)
    • Management
    • Resources
    • References

    CHAPTER 45: Autoinflammatory Diseases Presenting in the Skin

    • Overview
    • Introduction
    • MONOGENIC AUTOINFLAMMATORY SYNDROMES
    • COMPLEX AND POLYGENIC AUTOINFLAMMATORY DISEASES PRESENTING WITH URTICARIAL OR MACULOPAPULAR RASH
    • OTHER DISEASES IN WHICH AUTOINFLAMMATORY MECHANISMS MAY PLAY AN IMPORTANT ROLE
    • References

    CHAPTER 46: Mastocytosis

    • Overview
    • Definition and nomenclature
    • Classification
    • Introduction and general description
    • Aetiopathogenesis
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management (Box 46.5)
    • Resources
    • References

    CHAPTER 47: Reactive Inflammatory Erythemas

    • Overview
    • Introduction
    • Erythema multiforme
    • Annular erythema of infancy
    • Erythema annulare centrifugum
    • Erythema gyratum repens
    • Erythema marginatum
    • Necrolytic migratory erythema
    • References

    CHAPTER 48: Adamantiades–Behçet disease

    • Overview
    • Definition and nomenclature
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • References

    CHAPTER 49: Neutrophilic Dermatoses

    • Overview
    • Pyoderma Gangrenosum
    • Sweet syndrome (acute febrile neutrophilic dermatosis)
    • Bowel-associated dermatitis-arthritis syndrome
    • Subcorneal pustular dermatosis (Sneddon-Wilkinson)
    • Other neutrophilic dermatoses and variants
    • References

    CHAPTER 50: Immunobullous Diseases

    • Overview
    • Introduction
    • INTRAEPIDERMAL IMMUNOBULLOUS DISEASES
    • SUBEPIDERMAL IMMUNOBULLOUS DISEASES
    • References

    CHAPTER 51: Lupus Erythematosus

    • Overview
    • Introduction
    • Lupus erythematosus, discoid (chronic cutaneous)
    • Lupus erythematosus, subacute cutaneous
    • Lupus erythematosus, systemic
    • Lupus erythematosus. neonatal
    • References

    CHAPTER 52: Antiphospholipid syndrome

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • References

    CHAPTER 53: Dermatomyositis

    • Overview
    • Definition
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Resources
    • References

    CHAPTER 54: Mixed Connective Tissue Disease

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • References

    CHAPTER 55: Dermatological Manifestations of Rheumatoid Disease

    • Overview
    • Introduction
    • DERMATOLOGICAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS
    • OTHER RHEUMATOID DISEASES
    • References

    CHAPTER 56: Systemic Sclerosis (Systemic Scleroderma)

    • Overview
    • Definition and nomenclature
    • Classification
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Resources
    • References

    CHAPTER 57: Morphoea and Allied Scarring and Sclerosing Inflammatory Dermatoses

    • Overview
    • Definition and nomenclature
    • Classification
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Resources
    • References

Part 5 Metabolic and Nutritional Disorders Affecting the Skin

    CHAPTER 58: Cutaneous Amyloidoses

    • Overview
    • Introduction
    • Ultrastructure and amyloidogenesis
    • Functional and disease-causing amyloids
    • Basic classification
    • Clinical presentation
    • Investigations
    • Amyloidoses, localized cutaneous
    • Amyloidoses, cutaneous amyloidoses due to systemic disease
    • Management of cutaneous amyloidoses
    • References

    CHAPTER 59: Cutaneous Mucinoses

    • Overview
    • Introduction and general description
    • PRIMARY MUCINOSES
    • SECONDARY MUCINOSES
    • References

    CHAPTER 60: Cutaneous Porphyrias

    • Overview
    • Introduction
    • GENERAL CONSIDERATIONS: THEORETICAL BASIS, CLINICAL FEATURES AND LABORATORY TESTING IN PORPHYRIA
    • INDIVIDUAL PORPHYRIAS
    • References

    CHAPTER 61: Calcification of the Skin and Subcutaneous Tissues

    • Overview
    • Calcification (idiopathic) secondary to inflammatory disease and infections
    • Calcification (idiopathic) secondary to trauma or injection/infusion of calcium-containing materials
    • Calcification (idiopathic) secondary to tumours and genetic disease
    • Calcification (idiopathic) of the skin and subcutaneous tissues
    • Calcification, metastatic
    • Calciphylaxis
    • References

    CHAPTER 62: Xanthomas and Abnormalities of Lipid Metabolism and Storage

    • Overview
    • Introduction
    • Classification of dyslipidaemias
    • XANTHOMAS
    • PRIMARY DYSLIPIDAEMIAS: HYPERCHOLESTEROLAEMIA
    • PRIMARY DYSLIPIDAEMIAS: COMBINED DYSLIPIDAEMIA
    • PRIMARY DYSLIPIDAEMIAS: HYPERTRIGLYCERIDAEMIAS
    • OTHER PRIMARY DYSLIPIDAEMIAS
    • DYSLIPIDAEMIAS, SECONDARY
    • References

    CHAPTER 63: Nutritional Disorders Affecting the Skin

    • Overview
    • NUTRITION
    • VITAMINS
    • MINERALS
    • References

    CHAPTER 64: Skin Disorders in Diabetes Mellitus

    • Overview
    • Introduction
    • Diabetes mellitus: Vascular damage
    • Diabetes mellitus: Neurological damage
    • Diabetes mellitus: Infections
    • Obesity and hyperlipidaemia-related skin disease
    • Diabetes mellitus: Treatment-related skin manifestations
    • Diabetes mellitus: Disease associations and genetic syndromes
    • Miscellaneous
    • References

Part 6 Genetic Disorders Involving the Skin

    CHAPTER 65: Inherited Disorders of Cornification

    • Overview
    • Introduction
    • ICHTHYOSES (see Tables 65.1, 65.2, 65.3, 65.4, 65.5, 65.6, 65.7, 65.8)
    • PALMOPLANTAR KERATODERMA (see Tables 65.9, 65.11, 65.13, 65.14 and 65.15)
    • MISCELLANEOUS DISORDERS OF KERATINIZATION
    • References

    CHAPTER 66: Inherited Acantholytic Disorders

    • Overview
    • Darier disease
    • Hailey–Hailey disease
    • References

    CHAPTER 67: Ectodermal Dysplasias

    • Overview
    • Ectodermal dysplasias
    • Ectodermal dysplasia: X-linked hypohidrotic with immunodeficiency
    • Ectodermal dysplasia, hypohidrotic
    • Ankyloblepharon–ectodermal defect–cleft lip/palate syndrome
    • Ectrodactyly–ectodermal dysplasia–cleft lip/palate syndrome
    • Tricho–dento–osseous syndrome
    • Tricho-rhino-phalangeal syndrome
    • Ectodermal dysplasia, hidrotic
    • Focal dermal hypoplasia (Goltz syndrome)
    • MIDAS syndrome
    • Focal facial dermal dysplasia
    • References

    CHAPTER 68: Inherited Hair Disorders

    • Overview
    • Definition
    • Introduction and general description
    • HYPERTRICHOSES
    • ATRICHIAS
    • HYPOTRICHOSES
    • HAIR SHAFT STRUCTURAL ABNORMALITIES
    • OVERALL APPROACH TO THE DIAGNOSIS OF GENOTRICHOSES
    • References

    CHAPTER 69: Genetic Defects of Nails and Nail Growth

    • Overview
    • Pachyonychia congenita
    • Dyskeratosis congenita
    • Nail–patella syndrome
    • Anonychia, hereditary
    • References

    CHAPTER 70: Genetic Disorders of Pigmentation

    • Overview
    • Introduction and general description
    • HYPOPIGMENTATION DISORDERS
    • HYPERPIGMENTATION DISORDERS
    • DYSCHROMATOSES
    • References

    CHAPTER 71: Genetic Blistering Diseases

    • Overview
    • Introduction
    • Definition and classification
    • Prevalence and incidence
    • Skin proteins and genes implicated in epidermolysis bullosa
    • Other proteins and genes linked to skin fragility
    • Clinical subtypes
    • Diagnosis
    • Differential diagnosis
    • Other blistering genodermatoses
    • Treatment
    • Innovative therapies
    • References

    CHAPTER 72: Genetic Disorders of Collagen, Elastin and Dermal Matrix

    • Overview
    • INHERITED DISORDERS OF COLLAGEN
    • INHERITED DISORDERS OF ELASTIC FIBRES
    • INFANTILE STIFF SKIN SYNDROMES
    • PREMATURE AGEING SYNDROMES
    • DISORDERS OF ECTOPIC CALCIFICATION AND ABNORMAL MINERALIZATION
    • MISCELLANEOUS DERMAL DISORDERS
    • References

    CHAPTER 73: Disorders Affecting Cutaneous Vasculature

    • Overview
    • Introduction
    • CAPILLARY DISORDERS
    • ARTERIOVENOUS DISORDERS
    • VENOUS DISORDERS
    • LYMPHATIC DISORDERS
    • References

    CHAPTER 74: Genetic Disorders of Adipose Tissue

    • Overview
    • Introduction
    • Congenital (familial) lipodystrophies
    • Hereditary obesity
    • CLOVES syndrome
    • Panniculitis, hereditary
    • Familial lipoedema
    • References

    CHAPTER 75: Congenital Naevi and Other Developmental Abnormalities Affecting the Skin

    • Overview
    • CONGENITAL NAEVI
    • OTHER DEVELOPMENTAL ABNORMALITIES AFFECTING THE SKIN
    • References

    CHAPTER 76: Chromosomal Disorders

    • Overview
    • Introduction
    • AUTOSOMAL CHROMOSOME DEFECTS
    • SEX CHROMOSOME DEFECTS
    • CHROMOSOMAL MOSAICISM
    • References

    CHAPTER 77: Poikiloderma Syndromes

    • Overview
    • Introduction
    • Dyskeratosis congenita
    • Rothmund–Thomson syndrome
    • Poikiloderma with neutropenia, Clericuzio type
    • Hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis
    • Acrokeratotic poikiloderma of Weary
    • References

    CHAPTER 78: DNA Repair Disorders with Cutaneous Features

    • Overview
    • Introduction
    • Xeroderma pigmentosum
    • Cockayne syndrome
    • Trichothiodystrophy
    • OTHER DISORDERS
    • References

    CHAPTER 79: Syndromes with Premature Ageing

    • Overview
    • Introduction
    • Werner syndrome
    • Bloom syndrome
    • Progeroid laminopathies and related conditions
    • Hutchinson–Gilford progeria syndrome
    • Mandibulo-acral dysplasia with type A and type B lipodystrophy
    • Cutis laxa: autosomal dominant and autosomal recessive
    • References

    CHAPTER 80: Hamartoneoplastic Syndromes

    • Overview
    • Introduction
    • Neurofibromatosis
    • Tuberous sclerosis complex
    • Gardner syndrome
    • Cowden syndrome
    • References

    CHAPTER 81: Inherited Metabolic Diseases

    • Overview
    • Introduction
    • LYSOSOMAL STORAGE DISORDERS
    • MITOCHONDRIAL RESPIRATORY CHAIN DISORDERS
    • CONGENITAL DISORDERS OF GLYCOSYLATION
    • DISORDERS OF AMINO ACID METABOLISM AND TRANSPORT
    • DISORDERS OF CHOLESTEROL SYNTHESIS
    • OTHER METABOLIC DISORDERS
    • References

    CHAPTER 82: Inherited Immunodeficiency

    • Overview
    • Introduction
    • Diagnosis
    • Primary immunodeficiencies with skin manifestations
    • References

Part 7 Psychological, Sensory and Neurological Disorders and the Skin

    CHAPTER 83: Pruritus, Prurigo and Lichen Simplex

    • Overview
    • Pruritus
    • Prurigo nodularis
    • Lichen simplex chronicus
    • References

    CHAPTER 84: Mucocutaneous Pain Syndromes

    • Overview
    • Introduction
    • Burning mouth syndrome (orodynia and glossodynia)
    • Post-herpetic Neuralgia
    • Trigeminal neuropathic pain syndrome
    • Trigeminal trophic syndrome
    • Trigeminal trophic syndrome, atypical
    • Vulovodynia, scrotodynia and penodynia
    • Scalp pain, chronic
    • Erythromelalgia
    • References

    CHAPTER 85: Neurological Conditions Affecting the Skin

    • Overview
    • Introduction
    • Neuropathic ulcer
    • Syringomyelia
    • Spinal dysraphism
    • Spinal cord injury, dermatoses associated with
    • Neuropathy, hereditary sensory and autonomic
    • Sympathetic nerve injury
    • Complex regional pain syndrome
    • Horner syndrome
    • Gustatory hyperhidrosis
    • Restless legs syndrome/burning feet syndrome
    • References

    CHAPTER 86: Psychodermatology and Psychocutaneous Disease

    • Overview
    • Introduction
    • DELUSIONAL BELIEFS
    • OBSESSIVE AND COMPULSIVE BEHAVIOUR
    • EATING DISORDERS
    • PSYCHOGENIC ITCH
    • FACTITIOUS SKIN DISEASE
    • DELIBERATE SELF-HARM
    • OTHER PSYCHODERMATOLOGY AND PSYCHOCUTANEOUS DISEASES
    • References

Part 8 Skin Disorders Associated with Specific Cutaneous Structure

    CHAPTER 87: Acquired Disorders of Epidermal Keratinization

    • Overview
    • Ichthyosis, acquired
    • Acanthosis nigricans
    • Confluent and reticulated papillomatosis
    • Pityriasis rotunda
    • Keratosis pilaris
    • Lichen spinulosus
    • Keratosis circumscripta
    • Phrynoderma
    • Trichodysplasia spinulosa
    • Flegel disease
    • Keratoses, multiple minute digitate
    • Porokeratoses
    • Transient acantholytic dermatosis
    • Keratolysis exfoliativa
    • Xerosis cutis and asteatosis
    • Oedema blisters, acute, and acute epidermal distension
    • References

    CHAPTER 88: Acquired Pigmentary Disorders

    • Overview
    • SKIN PIGMENTATION AND THE MELANOCYTE
    • ACQUIRED HYPERMELANOSIS
    • ACQUIRED HYPOMELANOSIS (Figure 88.33)
    • NON-MELANIN PIGMENTATION
    • References

    CHAPTER 89: Acquired Disorders of Hair

    • Overview
    • HAIR BIOLOGY
    • APPROACH TO THE PATIENT WITH HAIR LOSS
    • NON-SCARRING DISORDERS OF HAIR GROWTH
    • SCARRING DISORDERS OF HAIR GROWTH
    • OTHER DISORDERS OF HAIR GROWTH
    • ABNORMALITIES OF THE HAIR SHAFT
    • EXCESSIVE GROWTH OF HAIR
    • HAIR PIGMENTATION
    • HAIR COSMETICS
    • References

    CHAPTER 90: Acne

    • Overview
    • Acne vulgaris
    • Acne fulminans
    • Acne conglobata
    • Occupational acne
    • Prepubertal acne
    • References

    CHAPTER 91: Rosacea

    • Overview
    • Definition and nomenclature
    • Classification and grading of severity
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • FACIAL DERMATOSES WITH AN UNCERTAIN NOSOLOGICAL RELATIONSHIP TO ROSACEA
    • References

    CHAPTER 92: Hidradenitis Suppurativa

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • References

    CHAPTER 93: Other Acquired Disorders of the Pilosebaceous Unit

    • Overview
    • Pseudofolliculitis
    • Folliculitis keloidalis
    • Folliculitis, necrotizing lymphocytic, of the scalp margin
    • Folliculitis, scalp
    • Folliculitis, actinic
    • Folliculitis: disseminate and recurrent infundibulofolliculitis
    • Folliculitis, eosinophilic pustular
    • Folliculitis, infantile eosinophilic pustular
    • Sebaceous glands, heterotopic (Fordyce spots)
    • Sebaceous gland hyperplasia
    • References

    CHAPTER 94: Disorders of the Sweat Glands

    • Overview
    • Introduction
    • ECCRINE GLANDS
    • DISORDERS OF ECCRINE SWEAT GLANDS
    • APOCRINE GLANDS
    • DISORDERS OF APOCRINE SWEAT GLANDS
    • References

    CHAPTER 95: Acquired Disorders of the Nails and Nail Unit

    • Overview
    • ANATOMY AND BIOLOGY OF THE NAIL UNIT
    • NAIL SIGNS AND THEIR SIGNIFICANCE
    • TRAUMATIC NAIL DISORDERS
    • TUMOURS UNDER OR ADJACENT TO THE NAIL
    • PERIONYCHIAL DISORDERS
    • DERMATOSES AFFECTING THE NAILS
    • NAILS IN CHILDHOOD AND OLD AGE
    • IMAGING OF THE NAIL
    • NAIL SURGERY
    • THE NAIL AND COSMETICS
    • Conclusion
    • References

    CHAPTER 96: Acquired Disorders of Dermal Connective Tissue

    • Overview
    • CHANGES IN DERMAL CONNECTIVE TISSUE DUE TO AGEING AND PHOTODAMAGE
    • OTHER CAUSES OF CUTANEOUS ATROPHY
    • DISORDERS OF ELASTIC FIBRE DEGRADATION
    • ACQUIRED DISORDERS OF ELASTIC TISSUE DEPOSITION
    • FIBROMATOSES AND OTHER CAUSES OF DIFFUSE FIBROSIS
    • ABNORMAL FIBROTIC RESPONSES TO SKIN INJURY
    • PERFORATING DERMATOSES
    • References

    CHAPTER 97: Granulomatous Disorders of the Skin

    • Overview
    • Granuloma annulare
    • Necrobiosis lipoidica
    • Cutaneous Crohn disease
    • References

    CHAPTER 98: Sarcoidosis

    • Overview
    • Definition
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • SPECIFIC FORMS OF CUTANEOUS SARCOIDOSIS
    • SPECIAL LOCATIONS OF SPECIFIC CUTANEOUS LESIONS
    • NON-SPECIFIC LESIONS
    • CUTANEOUS SARCOID REACTION
    • References

    CHAPTER 99: Panniculitis

    • Overview
    • ANATOMY AND PHYSIOLOGY OF SUBCUTANEOUS FAT
    • PANNICULITIS
    • References

    CHAPTER 100: Other Acquired Disorders of Subcutaneous Fat

    • Overview
    • Introduction
    • ACQUIRED LIPODYSTROPHY
    • FAT HYPERTROPHY
    • SUBCUTANEOUS LIPOMATOSIS
    • LIPOEDEMA
    • MISCELLANEOUS DISORDERS OF SUBCUTANEOUS FAT
    • References

Part 9 Vascular Disorders Involving the Skin

    CHAPTER 101: Purpura

    • Overview
    • Introduction
    • Classification of purpura
    • PURPURA DUE TO THROMBOCYTOPENIA OR PLATELET DEFECTS
    • NON-THROMBOCYTOPENIC VASCULAR CAUSES OF PURPURA AND SYNDROMES OF PRIMARY ECCHYMOTIC HAEMORRHAGE
    • PIGMENTED PURPURIC DERMATOSES
    • DISORDERS OF CUTANEOUS MICROVASCULAR OCCLUSION
    • References

    CHAPTER 102: Cutaneous Vasculitis

    • Overview
    • Overview
    • SINGLE-ORGAN SMALL-VESSEL VASCULITIS
    • SMALL-VESSEL IMMUNE COMPLEX-ASSOCIATED VASCULITIS
    • SMALL-VESSEL ANCA-ASSOCIATED VASCULITIS
    • MEDIUM-VESSEL VASCULITIS
    • LARGE-VESSEL VASCULITIS
    • References

    CHAPTER 103: Dermatoses Resulting from Disorders of the Veins and Arteries

    • Overview
    • ARTERIAL AND ARTERIOLAR DISORDERS
    • NEUROVASCULAR DISORDERS
    • TELANGIECTASES
    • MALFORMATIONS
    • VENOUS DISORDERS
    • References

    CHAPTER 104: Ulceration Resulting from Disorders of the Veins and Arteries

    • Overview
    • Introduction
    • References

    CHAPTER 105: Disorders of the Lymphatic Vessels

    • Overview
    • Introduction
    • CLINICAL PRESENTATIONS OF LYMPHATIC DYSFUNCTION
    • COMPLICATIONS OF LYMPHOEDEMA
    • IMAGING OF THE LYMPHATIC SYSTEM
    • LYMPHOEDEMA MANAGEMENT
    • References

    CHAPTER 106: Flushing and Blushing

    • Overview
    • Introduction
    • Epidemiology
    • Physiology
    • Pathophysiology of flushing
    • Psychosocial aspects of blushing
    • Clinical presentation
    • Investigations
    • Management
    • Complications
    • Prognosis
    • References

Part 10 Skin Disorders Associated with Specific Sites, Sex and Age

    CHAPTER 107: Dermatoses of the Scalp

    • Overview
    • SCALING DISORDERS OF THE SCALP
    • SECONDARY CICATRICIAL ALOPECIA
    • THICKENED SCALP DISORDERS
    • TUMOURS OF THE SCALP
    • INFECTIONS OF THE SCALP
    • PUSTULAR CONDITIONS OF THE SCALP
    • OTHER SCALP DISORDERS
    • References

    CHAPTER 108: Dermatoses of the External Ear

    • Overview
    • Introduction
    • Examination [16]
    • Developmental defects
    • Ageing changes
    • Traumatic conditions
    • Chondrodermatitis nodularis
    • Pseudocyst of the ear
    • Ear: manifestations of skin and systemic diseases
    • Ear: infections
    • Otitis externa
    • Otitis externa, necrotizing
    • Otomycosis
    • Ear: tumours
    • Squamous cell carcinoma of the auricle (pinna)
    • Squamous cell carcinoma of the external auditory canal
    • Miscellaneous conditions
    • References

    CHAPTER 109: Dermatoses of the Eye, Eyelids and Eyebrows

    • Overview
    • Introduction
    • Anatomy and physiology of the eye [1,2]
    • Glossary of ophthalmological terms
    • Disorders affecting the eyebrows and eyelashes
    • Abnormalities of the eyelids
    • SKIN DISEASES AFFECTING THE EYE AND EYELIDS
    • INFECTIONS
    • OTHER DISORDERS
    • References

    CHAPTER 110: Dermatoses of the Oral Cavity and Lips

    • Overview
    • Introduction
    • BIOLOGY OF THE MOUTH
    • EXAMINATION OF THE MOUTH AND PERIORAL REGION
    • DISORDERS AFFECTING THE ORAL MUCOSA OR LIPS
    • GENETIC DISORDERS AFFECTING THE ORAL MUCOSA OR LIPS
    • ACQUIRED LIP LESIONS
    • SYSTEMIC DISEASES: ORAL MANIFESTATONS
    • References

    CHAPTER 111: Dermatoses of the Male Genitalia

    • Overview
    • Introduction
    • History and examination
    • Investigations
    • Structure and function of the male genitalia
    • Normal variants
    • The foreskin
    • Circumcision
    • Congenital and developmental abnormalities
    • TRAUMA AND ARTEFACT
    • INFLAMMATORY DERMATOSES
    • MISCELLANEOUS INFLAMMATORY DERMATOSES
    • NON-SEXUALLY TRANSMITTED INFECTIONS
    • DERMATOLOGICAL ASPECTS OF SEXUALLY TRANSMITTED DISEASE
    • BENIGN TUMOURS
    • PRE-CANCEROUS DERMATOSES AND CARCINOMA IN SITU
    • SQUAMOUS CARCINOMA AND OTHER MALIGNANT NEOPLASMS
    • MISCELLANEOUS CUTANEOUS MALE GENITAL CONDITIONS
    • References

    CHAPTER 112: Dermatoses of the Female Genitalia

    • Overview
    • Introduction
    • Structure and function of the female genitalia
    • CONGENITAL ABNORMALITIES
    • GENODERMATOSES
    • INFLAMMATORY DERMATOSES OF THE VULVA
    • ULCERATIVE AND BULLOUS DISORDERS
    • PIGMENTARY DISORDERS
    • VULVAL OEDEMA
    • NON-SEXUALLY TRANSMITTED INFECTIONS
    • BENIGN TUMOURS
    • PRE-MALIGNANT CONDITIONS
    • MALIGNANT NEOPLASMS
    • PAIN DISORDERS
    • TRAUMATIC LESIONS
    • MISCELLANEOUS
    • References

    CHAPTER 113: Dermatoses of Perineal and Perianal Skin

    • Overview
    • Introduction
    • PERIANAL ITCHING
    • PERIANAL INFLAMMATORY DERMATOSES
    • PERIANAL REACTIONS TO DRUGS AND MEDICATION
    • INFECTIONS
    • OTHER DISEASES AND INFECTIONS
    • References

    CHAPTER 114: Cutaneous Complications of Stomas and Fistulae

    • Overview
    • Introduction
    • Peristomal allergic contact dermatitis
    • Peristomal infections
    • Peristomal skin disorders
    • Dermatoses associated with underlying bowel disease
    • Peristomal irritant skin reactions
    • References

    CHAPTER 115: Dermatoses of Pregnancy

    • Overview
    • PHYSIOLOGICAL SKIN CHANGES IN PREGNANCY
    • SKIN INFECTIONS
    • AUTOIMMUNE SKIN DISEASES
    • SKIN TUMOURS
    • INFLAMMATORY SKIN DISEASES
    • ITCHING
    • SPECIFIC DERMATOSES
    • GENERAL GUIDANCE ON SAFE TREATMENTS IN PREGNANCY
    • References

    CHAPTER 116: Dermatoses of the Neonate

    • Overview
    • INTRODUCTION
    • SKIN DISORDERS IN THE NEONATE
    • References

    CHAPTER 117: Dermatoses and Haemangiomas of Infancy

    • Overview
    • Introduction
    • INFANTILE DERMATOSES
    • INFANTILE AND CONGENITAL HAEMANGIOMAS
    • Appendix 117.1 Protocol for the use of propranolol in treating infantile haemangiomas
    • References

Part 11 Skin Disorders Caused by External Agents

    CHAPTER 118: Benign Cutaneous Adverse Reactions to Drugs

    • Overview
    • Drug-induced exanthem
    • Drug-induced pruritus
    • Drug-induced eczema
    • Drug-related intertriginous and flexural exanthem, symmetrical
    • Urticaria, angio-oedema and anaphylaxis, drug-induced
    • Drug-induced serum sickness-like reaction
    • Drug eruption, lichenoid
    • Drug eruption, fixed
    • Pityriasis rosea, drug-induced
    • Erythema nodosum, drug-induced
    • Drug-induced acneform eruptions
    • References

    CHAPTER 119: Severe Cutaneous Adverse Reactions to Drugs

    • Overview
    • Acute generalized exanthematous pustulosis (AGEP)
    • Drug reaction with eosinophilia and systemic symptoms (DRESS)
    • Drug-induced generalized exfoliative dermatitis
    • Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)
    • Resources
    • References

    CHAPTER 120: Cutaneous Side Effects of Chemotherapy and Radiotherapy

    • Overview
    • Chemotherapy-induced toxic erythema
    • Chemotherapy-induced papulopustular eruptions
    • Chemotherapy-induced mucositis
    • Chemotherapy-induced hair changes
    • Chemotherapy-induced nail changes
    • Chemotherapy-induced dyspigmentation
    • Chemotherapy-induced photosensitivity
    • Radiotherapy-associated recall reaction
    • Radiotherapy-associated skin side effects
    • References

    CHAPTER 121: Dermatoses Induced by Illicit Drugs

    • Overview
    • Introduction
    • Cannabis
    • Inhalants
    • Ecstasy
    • Methamphetamine
    • Cocaine
    • Heroin
    • Illicit drug-injecting: cutaneous side effects
    • References

    CHAPTER 122: Dermatological Manifestations of Metal Poisoning

    • Overview
    • Introduction
    • Antimony, cutaneous adverse effects of
    • Arsenic, cutaneous adverse effects of
    • Gold, cutaneous adverse effects of
    • Lead, cutaneous adverse effects of
    • Mercury, cutaneous adverse effects of
    • Selenium, cutaneous adverse effects of
    • Silver, cutaneous adverse effects of
    • Thallium, cutaneous adverse effects of
    • Reactions to other metals
    • References

    CHAPTER 123: Mechanical Injury to the Skin

    • Overview
    • OVERVIEW OF SKIN INJURY
    • BIOMECHANICAL CONSIDERATIONS
    • EFFECTS OF FRICTION
    • OTHER REACTIONS TO MECHANICAL INJURY
    • REACTIONS TO FOREIGN BODIES
    • OTHER SKIN INJURIES
    • References

    CHAPTER 124: Pressure Injury and Pressure Ulcers

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features and classification
    • Investigations: histopathology
    • Management
    • Treatment
    • Are pressure ulcers avoidable?
    • References

    CHAPTER 125: Cutaneous Reactions to Cold and Heat

    • Overview
    • PHYSIOLOGICAL REACTIONS TO COLD
    • DISEASES CAUSED OR AGGRAVATED BY COLD
    • PHYSIOLOGICAL REACTIONS TO HEAT AND INFRARED RADIATION
    • DISEASES CAUSED BY HEAT AND INFRARED RADIATION
    • References

    CHAPTER 126: Burns and Heat Injury

    • Overview
    • Introduction
    • Initial assessment, pre-hospital care and emergency treatment
    • Inhalation injury
    • Evaluation and early management of the burn wound
    • Infection control
    • Hypermetabolism
    • Summary and conclusions
    • Acknowledgement
    • References

    CHAPTER 127: Cutaneous Photosensitivity Diseases

    • Overview
    • Introduction
    • IDIOPATHIC (IMMUNOLOGICAL) PHOTODERMATOSES
    • DRUG- AND CHEMICAL-INDUCED PHOTOSENSITIVITY
    • PHOTOAGGRAVATED DERMATOSES
    • CLINICAL ASSESSMENT AND MANAGEMENT OF A PATIENT WITH SUSPECTED PHOTOSENSITIVITY
    • References

    CHAPTER 128: Allergic Contact Dermatitis

    • Overview
    • History
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology [1]
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Contact dermatitis, photoallergic
    • Urticaria, allergic contact
    • References

    CHAPTER 129: Irritant Contact Dermatitis

    • Overview
    • Irritant contact dermatitis
    • Urticaria, non-immune contact
    • Contact dermatitis, phototoxic
    • Subjective sensory irritation
    • Burns, chemical
    • References

    CHAPTER 130: Occupational Dermatology

    • Overview
    • Contact dermatitis, occupational irritant
    • Contact dermatitis, occupational allergic
    • Acne, occupational of chemical origin
    • Dyspigmentation, occupational
    • Occupationally induced skin tumours
    • Occupational vibration white finger
    • References

    CHAPTER 131: Stings and Bites

    • Overview
    • STINGS
    • BITES
    • Acknowledgement
    • References

Part 12 Neoplastic, Proliferative and Infiltrative Disorders Affecting the Skin

    CHAPTER 132: Benign Melanocytic Proliferations and Melanocytic Naevi

    • Overview
    • Freckle (ephelis)
    • LENTIGINES
    • MUCOSAL MELANOTIC LESIONS
    • DERMAL MELANOCYTIC LESIONS
    • CONGENITAL MELANOCYTIC NAEVI
    • COMMON ACQUIRED NAEVI
    • NAEVI IN UNUSUAL SITES
    • NAEVI WITH UNUSUAL MORPHOLOGY
    • OTHER NAEVI
    • References

    CHAPTER 133: Benign Keratinocytic Acanthomas and Proliferations

    • Overview
    • BENIGN KERATINOCYTIC ACANTHOMAS
    • OTHER BENIGN PROLIFERATIONS
    • References

    CHAPTER 134: Cutaneous Cysts

    • Overview
    • Introduction and general description
    • References

    CHAPTER 135: Lymphocytic Infiltrates

    • Overview
    • Pseudolymphoma
    • Pityriasis lichenoides
    • Parapsoriasis
    • Lymphocytoma cutis
    • Jessner’s lymphocytic infiltrate
    • References

    CHAPTER 136: Cutaneous Histiocytoses

    • Overview
    • Introduction
    • DISORDERS OF DENDRITIC CELLS
    • DISORDERS OF NON-DENDRITIC CELLS
    • NON-LANGERHANS CELL HISTIOCYTOSES
    • MALIGNANT HISTIOCYTOSES
    • References

    CHAPTER 137: Soft-tissue Tumours and Tumour-like Conditions

    • Overview
    • Introduction and general description
    • FIBROUS AND MYOFIBROBLASTIC TUMOURS
    • FIBROHISTIOCYTIC TUMOURS
    • VASCULAR TUMOURS
    • LYMPHATIC TUMOURS
    • TUMOURS OF PERIVASCULAR CELLS
    • PERIPHERAL NEUROECTODERMAL TUMOURS
    • TUMOURS OF MUSCLE
    • SKELETAL MUSCLE TUMOURS
    • TUMOURS OF FAT CELLS
    • TUMOURS OF UNCERTAIN HISTOGENESIS
    • References

    CHAPTER 138: Tumours of Skin Appendages

    • Overview
    • Introduction
    • HAIR FOLLICLE TUMOURS
    • EXTERNAL ROOT SHEATH TUMOURS
    • HAMARTOMAS AND HAIR GERM TUMOURS AND CYSTS
    • HAIR MATRIX TUMOURS
    • LESIONS OF HAIR FOLLICLE MESENCHYME
    • SEBACEOUS GLAND TUMOURS [1,2,3,4,5,6]
    • APOCRINE GLAND TUMOURS [1]
    • ECCRINE GLAND HAMARTOMAS AND TUMOURS
    • ECCRINE OR APOCRINE/FOLLICULAR TUMOURS
    • SWEAT GLAND CARCINOMAS, INCLUDING DUCTAL APOCRINE/FOLLICULAR CARCINOMAS
    • MISCELLANEOUS TUMOURS
    • References

    CHAPTER 139: Kaposi Sarcoma

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • References

    CHAPTER 140: Cutaneous Lymphomas

    • Overview
    • Introduction
    • PRIMARY CUTANEOUS T-CELL LYMPHOMAS
    • PRIMARY CUTANEOUS CD30+ LYMPHOPROLIFERATIVE DISORDERS
    • PRIMARY CUTANEOUS PERIPHERAL T-CELL LYMPHOMA (UNSPECIFIED)
    • PRIMARY CUTANEOUS B-CELL LYMPHOMAS
    • SECONDARY CUTANEOUS B-CELL LYMPHOMAS
    • SECONDARY CUTANEOUS T-CELL LYMPHOMAS
    • OTHER DISORDERS
    • References

    CHAPTER 141: Basal Cell Carcinoma

    • Overview
    • Basal cell carcinoma
    • Basal cell carcinoma, fibroepithelial (Fibroepithelioma of Pinkus)
    • Naevoid basal cell carcinoma syndrome (Gorlin Syndrome)
    • Bazex-Dupré-Christol syndrome
    • References

    CHAPTER 142: Squamous Cell Carcinoma and its Precursors

    • Overview
    • Introduction
    • LESIONS WITH UNCERTAIN OR UNPREDICTABLE MALIGNANT POTENTIAL
    • IN SITU CARCINOMA OF THE SKIN
    • SQUAMOUS CELL CARCINOMA, CUTANEOUS
    • KERATOACANTHOMAS AND ASSOCIATED SYNDROMES
    • References

    CHAPTER 143: Melanoma

    • Overview
    • MELANOMA CLINICOPATHOLOGY
    • MELANOMA SURGERY: BIOPSIES, WIDE RESECTION AND SENTINEL LYMPH NODE SAMPLING
    • SYSTEMIC TREATMENT OF MELANOMA
    • References

    CHAPTER 144: Dermoscopy of Melanoma and Naevi

    • Overview
    • Introduction
    • Benign dermoscopic patterns in naevi
    • Dermoscopy of melanoma
    • References

    CHAPTER 145: Merkel Cell Carcinoma

    • Overview
    • Definition and nomenclature
    • Introduction and general description
    • Epidemiology
    • Pathophysiology
    • Clinical features
    • Investigations
    • Management
    • Resources
    • References

    CHAPTER 146: Skin Cancer in the Immunocompromised Patient

    • Overview
    • Introduction
    • Epidemiology
    • Pathophysiology
    • Immunodeficiency: skin cancers
    • Management
    • Organizations for patients and health care professionals
    • Conclusion
    • References

Part 13 Systemic Disease and the Skin

    CHAPTER 147: Cutaneous Markers of Internal Malignancy

    • Overview
    • INTRODUCTION
    • GENODERMATOSES ASSOCIATED WITH INTERNAL MALIGNANCIES
    • IMMUNODEFICIENCY AND NEOPLASIA SYNDROMES: WISKOTT–ALDRICH AND CHÉDIAK–HIGASHI SYNDROMES, ATAXIA-TELANGIECTASIA, DYSKERATOSIS CONGENITA AND FANCONI ANAEMIA (see also Chapter 82)
    • PARANEOPLASTIC PHENOMENA INVOLVING THE SKIN
    • DERMATOSES ASSOCIATED WITH INTERNAL MALIGNANCIES
    • VASCULAR DISORDERS ASSOCIATED WITH INTERNAL MALIGNANCY
    • References

    CHAPTER 148: The Skin and Disorders of the Haematopoietic and Immune Systems

    • Overview
    • Introduction
    • Skin manifestations of haematological malignancies
    • SKIN DISORDERS CAUSED BY INFILTRATION OF THE SKIN WITH NEOPLASTIC CELLS
    • IMMUNOGLOBULIN DEPOSITION DISORDERS OF THE SKIN
    • PARANEOPLASTIC CONDITIONS STRONGLY ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCIES
    • PARANEOPLASTIC CONDITIONS OCCASIONALLY ASSOCIATED WITH HAEMATOLOGICAL NEOPLASMS
    • SYNDROMES ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCIES AND INVOLVING THE SKIN
    • SKIN INVOLVEMENT IN IDIOPATHIC LYMPHADENOPATHIES
    • IMMUNODEFICIENCY, PRIMARY: SKIN MANIFESTATIONS
    • IMMUNODEFICIENCY, ACQUIRED: SKIN MANIFESTATIONS
    • ANAEMIAS AND HAEMOGLOBINOPATHIES
    • TRANSFUSION REACTIONS
    • References

    CHAPTER 149: The Skin and Endocrine Disorders

    • Overview
    • Introduction and overview
    • Biological basis of dermatoendocrinology
    • Basics of clinical dermatoendocrinology
    • Systematic review of clinical dermatoendocrinology
    • Future perspectives
    • References

    CHAPTER 150: The Skin and Disorders of the Heart

    • Overview
    • Introduction
    • Skin signs of cardiac disease
    • HEREDITARY SYNDROMES
    • CARDIAC INVOLVEMENT IN DERMATOSES OR SYSTEMIC DISEASES WITH SKIN FEATURES
    • References

    CHAPTER 151: The Skin and Disorders of the Respiratory System

    • Overview
    • INTRODUCTION
    • ALLERGIC DISORDERS
    • AUTOIMMUNE DISORDERS
    • VASCULITIS
    • INFECTIONS
    • CONGENITAL AND INHERITED DISORDERS/GENETIC SYNDROMES
    • NEUTROPHILIC DERMATOSES
    • OTHER SYSTEMIC DISEASES
    • MISCELLANEOUS DISORDERS
    • References

    CHAPTER 152: The Skin and Disorders of the Digestive System

    • Overview
    • Introduction
    • OESOPHAGUS, STOMACH AND INTESTINE
    • LIVER AND GALL BLADDER
    • PANCREATIC DISEASE
    • DERMATOLOGICAL MANIFESTATIONS OF OTHER DISORDERS INVOLVING THE DIGESTIVE SYSTEM
    • References

    CHAPTER 153: The Skin and Disorders of the Kidney and Urinary Tract

    • Overview
    • INTRODUCTION
    • RENAL AND SKIN INVOLVEMENT IN HEREDITARY SYNDROMES
    • RENAL DISORDERS, SKIN SIGNS OF
    • RENAL AND SKIN INVOLVEMENT, ACQUIRED DISORDERS WITH
    • RENAL DISORDERS SECONDARY TO SKIN DISEASE
    • References

    CHAPTER 154: The Skin and Disorders of the Musculoskeletal System

    • Overview
    • Introduction
    • History and examination
    • INFECTIVE ARTHROPATHIES
    • INFLAMMATORY ARTHROPATHIES
    • OSTEOARTHRITIS
    • METABOLIC DISORDERS WITH MUSCULOSKELETAL AND CUTANEOUS INVOLVEMENT
    • AUTOINFLAMMATORY DISORDERS
    • INFLAMMATORY CHONDROPATHIES
    • MISCELLANEOUS DISORDERS INVOLVING THE SKIN AND MUSCULOSKELETAL SYSTEM
    • ANTIRHEUMATIC MEDICATION, ADVERSE CUTANEOUS REACTIONS TO
    • Acknowledgement
    • References

Part 14 Aesthetic Dermatology

    CHAPTER 155: Skin Ageing

    • Overview
    • Introduction
    • Clinical features
    • Genetics of skin ageing
    • Grading and measurement of skin ageing
    • Pathophysiology
    • Implications of skin ageing
    • References

    CHAPTER 156: Cosmeceuticals

    • Overview
    • Introduction
    • Antioxidants
    • Antiageing: lightening
    • Antiageing: rhytide reduction
    • Herbals and phytochemicals
    • Conclusions
    • References

    CHAPTER 157: Soft Tissue Augmentation (Fillers)

    • Overview
    • Introduction
    • Indications
    • Techniques
    • Fillers
    • Common injection errors and how to avoid them
    • Adverse reactions and their treatment
    • Fillers and different skin types
    • Acknowledgements
    • References

    CHAPTER 158: Aesthetic Uses of Botulinum Toxins

    • Overview
    • Introduction
    • History of clinical applications
    • Pharmacology and action of neurotoxins
    • Clinical applications of botulinum toxins in aesthetic dermatology
    • Adverse events
    • Combination treatment and future trends
    • References

    CHAPTER 159: Chemical Peels

    • Overview
    • Introduction
    • Basic chemistry
    • Depth of peels
    • Indications and contraindications
    • Pre-peel procedure
    • Peeling procedure
    • Post-peel care
    • Side effects and complications
    • Chemical peels in patients with skin of colour
    • References

    CHAPTER 160: Lasers and Energy-based Devices

    • Overview
    • Introduction
    • Vascular lesions
    • Pigmented lesions
    • Laser hair removal
    • Skin resurfacing
    • Skin tightening
    • Fat reduction/body contouring
    • Conclusions
    • References