OSTEOARTHRITIS
Author: Roland Moskowitz, MD, MS(MED), Roy Altman, MD, Marc Hochberg, MD, MPH, Joseph Buckwalter, MD, MS, Victor Goldberg, MD
Publisher: Lippincott Williams & Wilkins
Publication Date: 2007
Publisher: Lippincott Williams & Wilkins
Publication Date: 2007
ISBN 10: 0781767075
ISBN 13: 9780781767071
Edition: 4th
ISBN 13: 9780781767071
Edition: 4th
Description:
At a time when prevalence of osteoarthritis is increasing with an aging population it is timely to review the latest evidence and management strategies for optimal treatment of patients with this, the most common joint disease. A review of the current understanding of the management of this disorder and of the basic mechanisms involved provides the rationale for publication of this new fully-updated edition.
Table of Contents
Front Matter
I Basic Considerations
- RISK FACTORS FOR OSTEOARTHRITIS
- ARTICULAR CARTILAGE
- CHANGES IN THE CHONDROCYTE PHENOTYPE IN RELATIONSHIP TO CELL DEATH, MATRIX DEGRADATION, AND CALCIFICATION IN OSTEOARTHRITIS
- THE REMODELLING OF SUBCHONDRAL BONE IN OSTEOARTHRITIS
- SYNOVITIS AND INFLAMMATION IN OSTEOARTHRITIS
- THERAPEUTIC TARGETS FOR THE MANAGEMENT OF OSTEOARTHRITIS
- CONCLUSIONS
- ACKNOWLEDGMENTS
- REFERENCES
- INDUCTION OF OSTEOARTHRITIS BY INJECTION OF COMPOUNDS INTO JOINTS
- IMMOBILIZATION MODELS OF OSTEOARTHRITIS
- MODELS OF SPONTANEOUS OSTEOARTHRITIS
- OSTEOARTHRITIS IN GENETICALLY MODIFIED MICE
- SURGICALLY INDUCED DESTABILIZATION MODELS OF OSTEOARTHRITIS
- MISCELLANEOUS MODELS OF OSTEOARTHRITIS
- SUMMARY AND CONCLUSIONS
- REFERENCES
- OUTLINE
- GENOME-WIDE LINKAGE SCANS
- OSTEOARTHRITIS SUSCEPTIBILITY GENES DETECTED VIA THE GENOME-WIDE LINKAGE SCANS
- OSTEOARTHRITIS SUSCEPTIBILITY GENES DETECTED VIA GENOME-WIDE ASSOCIATION STUDIES
- OSTEOARTHRITIS SUSCEPTIBILITY GENES DETECTED VIA GENE EXPRESSION ANALYSIS
- CONCLUDING REMARKS
- ACKNOWLEDGMENTS
- REFERENCES
Epidemiology of Osteoarthritis
Etiopathogenesis of Osteoarthritis
Pathology of Osteoarthritis
Cell Biology, Biochemistry, and Molecular Biology of Articular Cartilage in Osteoarthritis
Experimental Models of Osteoarthritis
Molecular Genetics of Osteoarthritis
II General Aspects of Diagnosis
- IMAGING OSTEOARTHRITIS WITH MAGNETIC RESONANCE IMAGING
- MAGNETIC RESONANCE IMAGING TECHNIQUE
- IMAGING ARTICULAR CARTILAGE
- IMAGING OTHER ARTICULAR COMPONENTS IN OSTEOARTHRITIS
- CHALLENGES IN IMAGING SPECIFIC JOINTS
- ADVANCES IN MRI TECHNOLOGY AND THE IMPACT ON MAGNETIC RESONANCE IMAGING OF OSTEOARTHRITIS
- CONCLUSION
- REFERENCES
- SYSTEMIC METABOLIC DISEASES
- ENDOCRINE DISEASES
- CALCIUM CRYSTAL DEPOSITION DISEASES
- OTHER SYSTEMIC DISEASES
- OSTEOARTHRITIS FOLLOWING JOINT INJURY (POST-TRAUMATIC OSTEOARTHRITIS)
- JOINT DYSPLASIA
- OSTEOARTHRITIS AFTER MISCELLANEOUS SYSTEMIC DISEASES WITH OTHER INITIAL MECHANISMS OF JOINT DAMAGE
- CONCLUSION
- REFERENCES
Osteoarthritis: Clinical Presentations
Radiologic Diagnosis
Magnetic Resonance Imaging
Ultrasound and Alternative Imaging Outcomes
Laboratory Findings in Osteoarthritis
Noninvasive Biochemical Markers in Osteoarthritis
Secondary Osteoarthritis
III General Aspects of Management
- SIMPLE ANALGESICS
- TOPICAL ANALGESICS
- NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
- “CLASS” EFFECTS OF NSAIDs AND COX-2 INHIBITORS
- TRAMADOL
- OPIOID ANALGESICS
- INTRA-ARTICULAR THERAPY
- INTRA-ARTICULAR GLUCOCORTICOIDS
- DISEASE-MODIFYING OSTEOARTHRITIS DRUGS
- NUTRACEUTICALS AND OTHER INVESTIGATIONAL AGENTS
- SUMMARY AND GUIDELINES
- REFERENCES