OSTEOARTHRITIS This title has been archived.

Author: Roland Moskowitz, MD, MS(MED), Roy Altman, MD, Marc Hochberg, MD, MPH, Joseph Buckwalter, MD, MS, Victor Goldberg, MD
Affiliation: Case Western Reserve University School of Medicine
Publisher: Lippincott Williams & Wilkins
Publication Date: 2007
ISBN 10: 0781767075
ISBN 13: 9780781767071
Edition: 4th

Description:

At a time when prevalence of osteoarthritis is increasing with an aging population it is timely to review the latest evidence and management strategies for optimal treatment of patients with this, the most common joint disease. A review of the current understanding of the management of this disorder and of the basic mechanisms involved provides the rationale for publication of this new fully-updated edition.

Table of Contents

Front Matter

  • ABOUT
  • DEDICATION
  • Foreword
  • Preface
  • Contributors
  • Acknowledgments

I Basic Considerations

    1: Epidemiology of Osteoarthritis

    • INTRODUCTION
    • DEFINING OSTEOARTHRITIS
    • INCIDENCE
    • PREVALENCE
    • RISK FACTORS FOR INCIDENT OSTEOARTHRITIS
    • PROGRESSION OF OSTEOARTHRITIS
    • RISK FACTORS FOR PAIN AND DISABILITY IN OSTEOARTHRITIS
    • CONCLUSION
    • REFERENCES

    2: Etiopathogenesis of Osteoarthritis

    • RISK FACTORS FOR OSTEOARTHRITIS
    • ARTICULAR CARTILAGE
    • CHANGES IN THE CHONDROCYTE PHENOTYPE IN RELATIONSHIP TO CELL DEATH, MATRIX DEGRADATION, AND CALCIFICATION IN OSTEOARTHRITIS
    • THE REMODELLING OF SUBCHONDRAL BONE IN OSTEOARTHRITIS
    • SYNOVITIS AND INFLAMMATION IN OSTEOARTHRITIS
    • THERAPEUTIC TARGETS FOR THE MANAGEMENT OF OSTEOARTHRITIS
    • CONCLUSIONS
    • ACKNOWLEDGMENTS
    • REFERENCES

    3: Pathology of Osteoarthritis

    • HISTORICAL CONCEPTS OF OSTEOARTHRITIS
    • DEFINITIONS AND TERMINOLOGY
    • MICROSCOPIC ANATOMY OF NORMAL JOINTS
    • CURRENT HYPOTHESES REGARDING PATHOLOGIC LESIONS
    • VARIANTS OF OSTEOARTHRITIS
    • SUMMARY CONCEPTS
    • REFERENCES

    4: Cell Biology, Biochemistry, and Molecular Biology of Articular Cartilage in Osteoarthritis

    • CARTILAGE: TISSUE ORGANIZATION
    • CHONDROCYTE CELL BIOLOGY
    • BIOCHEMICAL COMPOSITION OF THE CARTILAGE EXTRACELLULAR MATRIX
    • NUTRITION OF ARTICULAR CARTILAGE
    • EXTRACELLULAR MATRIX BIOSYNTHESIS AND ASSEMBLY
    • PROTEINASES INVOLVED IN CARTILAGE MATRIX DEGRADATION
    • CHANGES IN OSTEOARTHRITIS
    • SUMMARY
    • REFERENCES

    5: Experimental Models of Osteoarthritis

    • INDUCTION OF OSTEOARTHRITIS BY INJECTION OF COMPOUNDS INTO JOINTS
    • IMMOBILIZATION MODELS OF OSTEOARTHRITIS
    • MODELS OF SPONTANEOUS OSTEOARTHRITIS
    • OSTEOARTHRITIS IN GENETICALLY MODIFIED MICE
    • SURGICALLY INDUCED DESTABILIZATION MODELS OF OSTEOARTHRITIS
    • MISCELLANEOUS MODELS OF OSTEOARTHRITIS
    • SUMMARY AND CONCLUSIONS
    • REFERENCES

    6: Molecular Genetics of Osteoarthritis

    • OUTLINE
    • GENOME-WIDE LINKAGE SCANS
    • OSTEOARTHRITIS SUSCEPTIBILITY GENES DETECTED VIA THE GENOME-WIDE LINKAGE SCANS
    • OSTEOARTHRITIS SUSCEPTIBILITY GENES DETECTED VIA GENOME-WIDE ASSOCIATION STUDIES
    • OSTEOARTHRITIS SUSCEPTIBILITY GENES DETECTED VIA GENE EXPRESSION ANALYSIS
    • CONCLUDING REMARKS
    • ACKNOWLEDGMENTS
    • REFERENCES

II General Aspects of Diagnosis

    7: Osteoarthritis: Clinical Presentations

    • CLINICAL MANIFESTATIONS
    • CLINICAL PRESENTATIONS
    • SPECIFIC SYNDROMES
    • CLINICAL DIFFERENTIAL DIAGNOSIS
    • SUMMARY
    • REFERENCES

    8: Radiologic Diagnosis

    • OSTEOARTHRITIS OF EXTRASPINAL LOCATIONS
    • OSTEOARTHRITIS OF THE SPINE
    • DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS
    • QUANTITATION OF RADIOLOGIC CHANGES
    • SUMMARY
    • REFERENCES

    9: Magnetic Resonance Imaging

    • IMAGING OSTEOARTHRITIS WITH MAGNETIC RESONANCE IMAGING
    • MAGNETIC RESONANCE IMAGING TECHNIQUE
    • IMAGING ARTICULAR CARTILAGE
    • IMAGING OTHER ARTICULAR COMPONENTS IN OSTEOARTHRITIS
    • CHALLENGES IN IMAGING SPECIFIC JOINTS
    • ADVANCES IN MRI TECHNOLOGY AND THE IMPACT ON MAGNETIC RESONANCE IMAGING OF OSTEOARTHRITIS
    • CONCLUSION
    • REFERENCES

    10: Ultrasound and Alternative Imaging Outcomes

    • ULTRASONOGRAPHY
    • COMPUTER TOMOGRAPHY
    • OPTICAL COHERENCE TOMOGRAPHY
    • SCINTIGRAPHY
    • POSITRON EMISSION TOMOGRAPHY
    • CONCLUSIONS
    • REFERENCES

    11: Laboratory Findings in Osteoarthritis

    • BLOOD
    • URINE
    • SYNOVIAL FLUID
    • SYNOVIAL HISTOLOGIC EXAMINATION
    • REFERENCES

    12: Noninvasive Biochemical Markers in Osteoarthritis

    • INTRODUCTION
    • ASSAYS FOR BIOCHEMICAL MARKERS OF JOINT TISSUE TURNOVER
    • CLINICAL USES OF BIOLOGICAL MARKERS FOR OSTEOARTHRITIS
    • CONCLUSION
    • REFERENCES

    13: Secondary Osteoarthritis

    • SYSTEMIC METABOLIC DISEASES
    • ENDOCRINE DISEASES
    • CALCIUM CRYSTAL DEPOSITION DISEASES
    • OTHER SYSTEMIC DISEASES
    • OSTEOARTHRITIS FOLLOWING JOINT INJURY (POST-TRAUMATIC OSTEOARTHRITIS)
    • JOINT DYSPLASIA
    • OSTEOARTHRITIS AFTER MISCELLANEOUS SYSTEMIC DISEASES WITH OTHER INITIAL MECHANISMS OF JOINT DAMAGE
    • CONCLUSION
    • REFERENCES

III General Aspects of Management

    14: Baseline Program

    • MANAGEMENT OBJECTIVES
    • REFERENCES

    15: The Pharmacologic Treatment of Osteoarthritis

    • SIMPLE ANALGESICS
    • TOPICAL ANALGESICS
    • NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
    • “CLASS” EFFECTS OF NSAIDs AND COX-2 INHIBITORS
    • TRAMADOL
    • OPIOID ANALGESICS
    • INTRA-ARTICULAR THERAPY
    • INTRA-ARTICULAR GLUCOCORTICOIDS
    • DISEASE-MODIFYING OSTEOARTHRITIS DRUGS
    • NUTRACEUTICALS AND OTHER INVESTIGATIONAL AGENTS
    • SUMMARY AND GUIDELINES
    • REFERENCES

    16: Intra-Articular Therapy

    • INTRA-ARTICULAR STEROIDS IN OSTEOARTHRITIS
    • NONSTEROIDAL INTRA-ARTICULAR THERAPEUTIC AGENTS
    • INTRA-ARTICULAR HYALURONATE (HYALURONIC ACID, HYALURONAN)
    • REFERENCES

    17: Complementary and Alternative Medicine

    • INTRODUCTION
    • GLUCOSAMINE
    • CHONDROITIN SULFATE
    • VITAMINS
    • HERBAL SUPPLEMENTS
    • METHYLSULFONYL METHANE
    • NONPHARMACOLOGIC INTERVENTIONS
    • CONCLUSION
    • REFERENCES

    18: Study Design and Outcome Measures in Osteoarthritis Clinical Trials

    • DESIGN OF CLINICAL TRIALS IN OSTEOARTHRITIS
    • REGISTRATION OF THERAPEUTIC AGENTS FOR OSTEOARTHRITIS: THE REGULATORY PATHWAY
    • INSTRUCTIVE EXAMPLES FROM RECENT RANDOMIZED CONTROLLED TRIALS
    • SUMMARY
    • REFERENCES

IV Surgical Considerations in Osteoarthritis

    19: General Considerations, Indications, and Outcomes

    • GENERAL CONSIDERATIONS
    • TYPES OF SURGICAL PROCEDURES
    • CONCLUSION
    • REFERENCES

    20A: Upper Extremity Considerations: Osteoarthritis of the Shoulder

    • GLENOHUMERAL JOINT
    • ANATOMY AND PATHOPHYSIOLOGY
    • CLINICAL EVALUATION
    • TREATMENT OPTIONS
    • RESULTS
    • COMPLICATIONS
    • SUMMARY
    • ACROMIOCLAVICULAR JOINT
    • REFERENCES

    20B: Upper Extremity Considerations: Hand, Wrist, and Elbow

    • DISTAL INTERPHALANGEAL JOINT
    • PROXIMAL INTERPHALANGEAL JOINT
    • METACARPOPHALANGEAL JOINT
    • CARPOMETACARPAL JOINTS
    • THUMB CARPOMETACARPAL JOINT
    • SCAPHOTRAPEZIOTRAPEZOIDAL JOINT
    • RADIOCARPAL JOINT
    • DISTAL RADIOULNAR JOINT
    • ELBOW
    • SUMMARY
    • REFERENCES

    21A: Lower Extremity Considerations: Hip

    • INTRODUCTION
    • ARTHROSCOPY
    • ARTHRODESIS
    • OSTEOTOMY
    • PELVIC OSTEOTOMY
    • HIP JOINT ARTHROPLASTY
    • COMPLICATIONS
    • SUMMARY
    • REFERENCES

    21B: Lower Extremity Considerations: Knee

    • OSTEOARTHRITIS OF THE KNEE
    • PATELLOFEMORAL JOINT DISORDERS
    • SUMMARY
    • REFERENCES

    21C: Lower Extremity Considerations: Foot and Ankle

    • OVERVIEW OF OSTEOARTHRITIS IN THE FOOT AND ANKLE
    • PRINCIPLES OF NONOPERATIVE TREATMENT OF OSTEOARTHRITIS OF THE ANKLE AND FOOT
    • PRINCIPLES OF OPERATIVE TREATMENT OF OSTEOARTHRITIS OF THE FOOT AND ANKLE
    • SUMMARY
    • REFERENCES

    22: Osteoarthritis of the Spine

    • CERVICAL SPINE
    • THORACIC SPINE
    • LUMBAR SPINE
    • REFERENCES

    23: New Frontiers in Surgery of Osteoarthritis

    • INTRODUCTION
    • SURGICAL TREATMENT OF CHONDRAL DEFECTS
    • CARTILAGE REPLACEMENT TECHNIQUES
    • NEW DEVELOPMENTS
    • SUMMARY
    • REFERENCES