CLINICAL AND DIAGNOSTIC VIROLOGY

Author: Goura Kudesia, Tim Wreghitt
Affiliation: University of Sheffield, UK
Publisher: Cambridge University Press
Publication Date: 2009
ISBN 10: 0521694671
ISBN 13: 9780521694674
Edition: 1st

Description:

This basic but comprehensive text is aimed at all healthcare professionals who need a clear understanding of medical virology. Written by two highly experienced virologists, the book is divided into five sections: 1) Individual viruses; 2) Other related agents; 3) Clinical syndromes; 4) Diagnostic techniques; 5) Patient management. The individual virus chapters provide information on incubation period, infectivity, control of infection and management. The clinical syndrome chapters provide information on the clinical presentation of disease, thus enabling the reader to search according to patient symptoms rather than referring to several individual virus chapters. The standard chapter formats, simple language and liberal use of tables, figures and algorithms enable quick access to key information, and the comprehensive coverage of all viral agents is unique in a practical guide of this size.

Table of Contents

Front Matter

  • ABOUT
  • Preface
  • Acknowledgements

Section 1 – Individual viruses

    Adenoviruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Arboviruses and haemorrhagic fever viruses

    • Haemorrhagic fever viruses
    • Specimens for diagnosis
    • Arboviruses
    • Specimens for diagnosis
    • Useful websites

    Cytomegalovirus (CMV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Epstein–Barr virus (EBV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Enteroviruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Hepatitis A virus (HAV)

    • The virus
    • Epidemiology
    • Clinical
    • Management
    • Infection control

    Hepatitis B and D viruses (HBV and HDV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Prophylaxis
    • Control of infection
    • Hepatitis D (Hepatitis delta)

    Hepatitis C virus (HCV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Hepatitis E virus (HEV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Herpes simplex virus (HSV)

    • The virus
    • Epidemiology
    • Clinical
    • Management
    • Infection control

    Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control
    • Useful website

    Human herpes viruses types 6, 7 and 8 (HHV 6, 7 and 8)

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Human T-cell leukaemia virus (HTLV)

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Influenza viruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Measles virus

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Mumps virus

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Noroviruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Parainfluenza viruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Papilloma and polyoma viruses

    • The viruses
    • Papilloma viruses
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control
    • Polyoma viruses

    Parvovirus B19

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Pox viruses

    • The viruses
    • Laboratory diagnosis

    Rabies virus

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Respiratory syncytial virus (RSV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Rhinoviruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Rotavirus

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Rubella virus

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory Diagnosis
    • Management
    • Infection control

    SARS CoV and other coronaviruses

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control
    • Useful website

    Varicella-zoster virus (VZV)

    • The virus
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

Section 2 – Other related agents

    Chlamydia

    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Toxoplasma gondii

    • The organism
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Transmissible spongiform encephalopathies (CJD and vCJD)

    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

Section 3 – Clinical syndromes

    Central nervous system viral infections

    • Clinical
    • Laboratory diagnosis

    Viral eye infections

    • Conjunctivitis
    • Keratitis

    The common cold

    • The viruses
    • Epidemiology
    • Clinical
    • Laboratory diagnosis
    • Management
    • Infection control

    Respiratory virus infections

    • Clinical
    • Laboratory diagnosis
    • Infection control

    Atypical pneumonia

    • Epidemiology
    • Laboratory diagnosis

    Gastroenteritis viruses

    • Clinical
    • Epidemiology
    • Laboratory diagnosis
    • Treatment

    Viral hepatitis

    • Clinical
    • Differential diagnosis
    • Epidemiology
    • Laboratory investigations
    • Management

    Genital tract and sexually transmitted infections (STIs)

    • Clinical
    • Localized genital symptoms
    • Prostatitis and epididymo-orchitis
    • Pelvic inflammatory disease (PID)
    • Genital infection in pregnancy
    • Laboratory diagnosis
    • Management

    Glandular fever-type illness

    • Clinical

    Viral rashes and skin infections

    • Clinical

    Infections in pregnancy, congenital and neonatal infections

    • Congenital infection
    • Perinatal infection
    • Postnatal infection
    • Management of neonatal herpes infection
    • Management of maternal genital herpes infection
    • Follow up of babies suspected of vertically acquired infection
    • Laboratory diagnosis

    Virus infections in immunocompromised patients

    • Organ transplant recipients
    • Bone marrow transplant patients
    • HIV antibody positive/AIDS patients

    Viral malignancies

    • How do viruses cause cancer?
    • Human malignancies and their viral causes
    • Control of viral malignancies

    Travel-related infections

    • Gastroenteritis
    • Pyrexia of unknown origin (PUO)
    • Respiratory infections
    • Hepatitis
    • Rabies
    • Infections associated with medical tourism
    • Miscellaneous infections

Section 4 – Diagnostic techniques

    Sending specimens to the laboratory

    • Sending the correct specimens
    • Filling in the specimen request form correctly
    • Packaging specimens correctly
    • Notifying the laboratory that urgent/important specimens are being sent
    • Ideal specimen request form

    Serological techniques

    • Principle of serological techniques
    • Techniques
    • Use of non-serum samples for antibody tests
    • Automation in serology
    • Future of serology
    • Conclusion

    Virus detection

    • Virus or cell culture
    • Electron microscopy
    • Antigen detection
    • Viral genome detection (RNA or DNA) by molecular techniques

    Molecular techniques

    • DNA or RNA hybridization
    • Polymerase chain reaction (PCR)
    • Nucleic acid sequencing
    • Technical consideration for molecular assays
    • Future of molecular assays

Section 5 – Patient management

    Antiviral drugs

    • Human immunodeficiency virus (HIV)
    • Herpes viruses
    • Respiratory viruses
    • Hepatitis viruses
    • Antiretrovirals
    • Useful websites

    Viral vaccines

    • Attenuated vaccines
    • Killed or inactivated virus vaccines
    • Passive immunization
    • Vaccination programmes
    • Post-exposure prophylaxis
    • Public health aspects of immunization
    • Useful websites

    Infection control

    • Viruses and their route of entry and spread
    • Control of infection
    • Outbreaks

    Occupational health

    • Introduction
    • Pre-employment health check
    • Vaccination
    • Needle-stick injuries
    • Outbreak control