EVIDENCE-BASED PHARMACOTHERAPY This title has been archived.

Author: Elaine Chiquette, and L. Posey
Affiliation:
Publisher: American Pharmacists Association
Publication Date: 2007
ISBN 10: 1582120684
ISBN 13: 9781582120683
Edition: 1st

Description:

An introductory textbook that explains the connection between research and practice, Evidence-Based Pharmacotherapy is a practicalguide for clinicians seeking to incorporate evidence-based medicine into their medication decisions. The book covers all aspects of accessing, interpreting, and applying the best knowledge about medications to ensure optimal patient care.

Table of Contents

Front Matter

  • ABOUT
  • NOTE
  • FOREWORD
  • PREFACE
  • CONTRIBUTORS

INTRODUCTION TO EVIDENCE-BASED PHARMACOTHERAPY

  • Becoming Interpreters of Drug Information
  • History of Evidence-Based Medicine
  • Making the Move Toward Evidence-Based Practice
  • References
  • Appendix 1-A GLOSSARY OF EVIDENCE-BASED MEDICAL TERMS

SEARCHING THE BIOMEDICAL LITERATURE: FINDING A NEEDLE IN A HAYSTACK

  • Identifying Background Versus Foreground Questions
  • Searching the Best Source
  • Reformulate the Question
  • Additional Reading
  • References
  • Appendix 2–A APPLY YOUR SEARCHING SKILLS
  • Appendix 2–B RESOURCES FOR LOCATING EVIDENCE-BASED MEDICAL INFORMATION

MATCHING THE QUESTION WITH THE BEST AVAILABLE EVIDENCE

  • Rappelling the Mountain of Evidence
  • Climbing the Evidence Ladder
  • Selecting the Best Available Evidence
  • Assessing Validity of Randomized Controlled Trials 15
  • Assessing Validity of Systematic Reviews 20 , 21
  • Assessing Validity of a Cohort Study 24
  • Assessing Validity of a Case–Control Study
  • Case Reports and Case Series 25
  • Grading Recommendations According to the Evidence Ladder
  • References
  • Appendix 3–A BASIC DESIGNS OF CLINICAL RESEARCH
  • Appendix 3–B APPLY YOUR CRITICAL APPRAISAL SKILLS
  • Appendix 3–C ADDITIONAL SUGGESTED READING ON CRITICAL APPRAISAL SKILLS

DEMYSTIFYING STATISTICS

  • Examining Variability
  • Relationships
  • Strength of the Evidence
  • Conclusion
  • Appendix 4–A GLOSSARY OF STATISTICAL TERMS
  • Appendix 4–B APPLY YOUR STATISTICAL SKILLS

TRANSFORMING EVIDENCE INTO ACTION

  • Outcomes That Matter
  • Surrogate Outcomes
  • Combining Outcomes
  • Magnitude of the Effect
  • How to Interpret the Numbers
  • Precision of the Effect 10
  • External Validity 11
  • Balance Sheet
  • References
  • Appendix 5–A APPLY YOUR TRANSLATIONAL, INTERPRETIVE, AND DECISION-MAKING SKILLS

MAKING A PHARMACOTHERAPY DECISION USING A DECISION-ANALYTIC FRAMEWORK

  • Step 1. Define the Context of the Decision
  • Step 2. Build a Decision Tree
  • Step 3. Assign Probabilities to the Decision Pathways
  • Step 4. Determine the Value and Outcomes of Each Pathway
  • Step 5. Select the Decision Option With the Best Outcome
  • Step 6. Test the Robustness of the Chosen Decision Option
  • The Role of Markov Modeling
  • Conclusion
  • References
  • Appendix 6–A APPLY YOUR SKILLS IN PHARMACOECONOMICS

APPLYING EVIDENCE-BASED PHARMACOTHERAPY TO FORMULARY DECISIONS

  • The Formulary
  • The Use of Science in Clinical Decision Making
  • Scientific, Clinical, and Economic Drug Review Processes: Introduction to a Method for Applying an “Explicit” Evidence- and Value-Based Approach
  • Conclusion
  • References
  • Appendix 7–A GLOSSARY OF DRUG REVIEW TERMS

KEEPING UP TO DATE

  • Clinical Research: Sorting Out the Cacophony of Evidence
  • Bibliographic Management Software
  • PEACEFUL: Getting the Most from Pharmaceutical Industry Field Representative Visits
  • References
  • APPENDIX 8–A PEACEFUL: APPRAISAL TOOL FOR A FOCUSED, COMPREHENSIVE INTERACTION WITH PHARMACEUTICAL FIELD REPRESENTATIVES