PHARMACEUTICAL COMPOUNDING AND DISPENSING This title has been archived.

Author: John Marriott, Keith Wilson, Christopher Langley, Dawn Belcher
Affiliation: Aston University School of Pharmacy, UK
Publisher: Pharmaceutical Press
Publication Date: 2006
ISBN 10: 085369575X
ISBN 13: 9780853695752
Edition: 1st

Description:

This new title is a modern, detailed and practical guide to the theory and practice of extemporaneous compounding and dispensing, and a source of reference for extemporaneous formulae. Written by experts and split over three key sections, Pharmaceutical Compounding and Dispensing will equip pharmacy students and practising pharmacists with the knowledge required to produce extemporaneous formulations safely and effectively.

Table of Contents

Front Matter

  • ABOUT
  • About the authors
  • Preface
  • Acknowledgements
  • Museum of the Royal Pharmaceutical Society
  • British Society for the History of Pharmacy

Part 1 History of compounding

    Historical perspective

    • 1.1 The origins of the pharmacy profession
    • 1.2 Foundation of the Royal Pharmaceutical Society of Great Britain
    • 1.3 Pharmacy legislation
    • 1.4 Development of the pharmacopoeias

    Obsolete dosage forms, equipment and methods of preparation

    • 2.1 Obsolete pharmaceutical preparations and preparative methods
    • 2.2 Old pharmaceutical equipment
    • 2.3 Old pharmaceutical containers

    Historical weights and measures

    • 3.1 Metrication

Part 2 Pharmaceutical forms and their preparation

    Key formulation skills

    • 4.1 Weights and measures
    • 4.2 Medication strength

    Extemporaneous dispensing

    • 5.1 Guide to general good practice requirements
    • 5.2 Suitable record keeping
    • 5.3 Equipment
    • 5.4 Product formulae
    • 5.5 Ingredients
    • 5.6 Storage and labelling requirements
    • 5.7 Pharmaceutical packaging

    Solutions

    • 6.1 Introduction and overview
    • 6.2 General principles of solution preparation
    • 6.3 Oral solutions
    • 6.4 Gargles and mouthwashes
    • 6.5 Enemas and douches
    • 6.6 External solutions
    • 6.7 Worked examples
    • 6.8 Summary of essential principles relating to solutions

    Suspensions

    • 7.1 Introduction and overview
    • 7.2 General principles of suspension preparation
    • 7.3 Oral diffusible suspensions
    • 7.4 Oral indiffusible suspensions
    • 7.5 Suspensions for external use
    • 7.6 Worked examples
    • 7.7 Summary of essential principles relating to suspensions

    Emulsions

    • 8.1 Introduction and overview
    • 8.2 Formulation of emulsions
    • 8.3 General method of preparation of an emulsion using the dry gum method
    • 8.4 Stability of emulsions
    • 8.5 Emulsions for external use
    • 8.6 Worked examples
    • 8.7 Summary of essential principles relating to emulsions

    Creams

    • 9.1 Introduction and overview
    • 9.2 Terminology used in the preparation of creams, ointments, pastes and gels
    • 9.3 General principles of cream preparation
    • 9.4 Worked examples
    • 9.5 Summary of essential principles relating to creams

    Ointments, pastes and gels

    • 10.1 Introduction and overview
    • 10.2 Ointments
    • 10.3 Pastes
    • 10.4 Gels
    • 10.5 Worked examples
    • 10.6 Summary of essential principles relating to ointments, pastes and gels

    Suppositories and pessaries

    • 11.1 Introduction and overview
    • 11.2 General principles of suppository and pessary preparation
    • 11.3 General method for suppository preparation
    • 11.4 Worked examples
    • 11.5 Summary of essential principles relating to suppositories and pessaries

    Powders and capsules

    • 12.1 Introduction and overview
    • 12.2 Bulk powders for external use
    • 12.3 Bulk oral powders
    • 12.4 Individual unit dose powders
    • 12.5 Unit dose capsules
    • 12.6 Worked examples
    • 12.7 Summary of essential principles relating to powders and capsules

    Specialised formulation issues

    • 13.1 Introduction and overview
    • 13.2 Posology
    • 13.3 Dermatological extemporaneous formulation

    Further reading

    Part 3 Product formulae

      Creams

      • 14.1 Cetrimide Cream BP (Cremor Cetrimidi) (BP 1988, page 653)
      • 14.2 Dimethicone Cream BPC (Cremor Dimethiconi) (BPC 1973, page 657)
      • 14.3 Salicylic Acid and Sulphur Cream BP (Cremor Acidi Salicylici et Sulphuris) (BP 1980, page 548)
      • 14.4 Zinc and Ichthammol Cream BP (Cremor Zinci et Ichthammolis) (BP 1988, page 666)
      • 14.5 Calamine Cream Aqueous BPC (Cremor Calaminae Aquosus) (BPC, 1973, page 656)
      • 14.6 Buffered Cream BP (Cremor Normalis) (BP 1988, page 652)
      • 14.7 Aqueous Cream BP (Cremor Cerae Aquos – also known as Simple Cream) (BP 1988, page 650)
      • 14.8 Zinc Cream BP (BP 1988, page 665)
      • 14.9 Cetomacrogol Cream BP (BP 1988, page 653)
      • 14.10 Chlorhexidine Cream BPC (Cremor Chlorhexidinae) (BPC 1973, page 657)
      • 14.11 Clioquinol Cream BPC (BPC 1973, page 658)
      • 14.12 Hydrocortisone Cream BPC (Cremor Hydrocortisoni) (BPC 1973, page 659)

      Dusting powders

      • 15.1 Chlorhexidine Dusting Powder BPC (BPC 1973, page 662)
      • 15.2 Hexachlorophane Dusting Powder BPC (BPC 1973, page 663)
      • 15.3 Talc Dusting Powder BP (Conspersus Talci) (BP 1988, page 668)
      • 15.4 Zinc, Starch and Talc Dusting Powder BPC (Conspersus Zinci, Amyli et Talci) (BPC 1973, page 664)

      Internal mixtures

      • 16.1 Saline Mixture BPC (Mistura Diaphoretica) (BPC 1968, page 1185)
      • 16.2 Belladonna Mixture Paediatric BPC (Mistura Belladonna pro Infantibus) (BPC 1973, page 737)
      • 16.3 Gentian and Rhubarb Mixture BPC (Mistura Gentianae cum Rheo) (BPC 1973, page 744)
      • 16.4 Magnesium Carbonate Mixture BPC (Mistura Magnesii Carbonatis) (BPC 1973, page 746)
      • 16.5 Aromatic Magnesium Carbonate Mixture BPC (Mistura Carminativa) (BPC 1973, page 746)
      • 16.6 Magnesium Sulphate Mixture BPC (Mistura Alba) (BPC 1973, page 747)
      • 16.7 Potassium Citrate Mixture BP (Mistura Potassii Citratis) (BP 1988, page 748)
      • 16.8 Paediatric Chalk Mixture BP (Mistura Cretae pro Infantibus) (BP 1988, page 724)
      • 16.9 Ammonia and Ipecacuanha Mixture BP (Mistura Expectorans) (BP 1988, page 719)
      • 16.10 Ferrous Sulphate Mixture Paediatric BP (Mistura Ferri Sulphatis pro Infantibus) (BP 1988, page 734)
      • 16.11 Aluminium Hydroxide and Belladonna Mixture BPC (BPC 1973, page 735)
      • 16.12 Compound Calcium Carbonate Mixture Paediatric BPC (Mistura Calcii Carbonatis Composita pro Infantibus) (BPC 1968, page 1158)
      • 16.13 Cascara and Belladonna Mixture BPC (Mistura Cascarae et Belladonnae) (BPC 1973, page 738)
      • 16.14 Colchicum and Sodium Salicylate Mixture BPC (Mistura Colchici et Sodii Salicylate) (BPC 1973, page 740)
      • 16.15 Gelsemium and Hyoscyamus Mixture Compound BPC (Mistura Gelsemii et Hyoscyami Composita) (BPC 1973, page 743)
      • 16.16 Gentian Acid Mixture with Nux Vomica BPC (Mistura Gentianae Acida cum Nuce Vomica) (BPC 1973, page 743)
      • 16.17 Gentian Alkaline Mixture with Nux Vomica BPC (Mistura Gentianae Alkalina cum Nuce Vomica) (BPC 1973, page 744)
      • 16.18 Alkaline Gentian Mixture with Phenobarbitone BPC (Mistura Gentianae Alkalina cum Phenobarbitono) (BPC 1973, page 744)
      • 16.19 Ipecacuanha and Squill Linctus Paediatric BPC (Mist Tussi Rubra pro Inf) (BPC 1973, page 723)
      • 16.20 Ipecacuanha Mixture Paediatric BPC (Mistura Ipecacuanha pro Infantibus) (BPC 1973, page 744)
      • 16.21 Paediatric Opiate Ipecacuanha Mixture BPC (BPC 1973, page 744)
      • 16.22 Ipecacuanha and Ammonia Mixture Paediatric BPC (Mistura Ipecacuanhae et Ammoniae pro Infantibus) (BPC 1973, page 745)
      • 16.23 Lobelia and Stramonium Mixture Compound BPC (Mistura Lobeliae et Stramonii Composta) (BPC 1973, page 746)
      • 16.24 Nux Vomica Mixture Acid BPC (Mistura Nucis Vomicae Acida) (BPC 1973, page 748)
      • 16.25 Nux Vomica Mixture Alkaline BPC (Mistura Nucis Vomicae Alkalina) (BPC 1973, page 749)
      • 16.26 Compound Camphorated Opium Mixture BPC (Mistura Opii Camphorata Composita) (BPC 1973, page 749)
      • 16.27 Potassium Citrate and Hyoscyamus Mixture BPC (Mistura Potassii Citratis et Hyoscyamus) (BPC 1973, page 751)
      • 16.28 Ammoniated Potassium Iodide Mixture BPC (Mistura Potassii Iodide Ammoniata) (BPC 1973, page 751)
      • 16.29 Compound Rhubarb Mixture BPC (Mistura Rhei Composita) (BPC 1973, page 752)
      • 16.30 Compound Rhubarb Mixture Paediatric BPC (Mistura Rhei Composita pro Infantibus) (BPC 1973, page 752)
      • 16.31 Ammoniated Rhubarb and Soda Mixture BPC (Mistura Rhei Ammoniate et Sodae) (BPC 1973, page 752)
      • 16.32 Compound Sodium Chloride Mixture BPC (Mistura Sodii Chloridi Composita) (BPC 1973, page 753)
      • 16.33 Sodium Citrate Mixture BPC (Mistura Sodium Citratis) (BPC 1973, page 753)
      • 16.34 Sodium Salicylate Mixture BPC (Mistura Sodii Salicylatis) (BPC 1973, page 753)
      • 16.35 Stramonium and Potassium Iodide Mixture BPC (Mistura Stramonii et Potassii Iodidi) (BPC 1973, page 753)
      • 16.36 Gentian Alkaline Mixture BP (Mistura Gentianae cum Soda) (BP 1988, page 736)
      • 16.37 Gentian Acid Mixture BPC (Mistura Gentianae Acida) (BPC 1973, page 743)
      • 16.38 Magnesium Trisilicate Mixture BP (Mistura Magnesii Trisilicatis) (BP 1988, page 740)
      • 16.39 Sodium Salicylate Mixture Strong BP (Mistura Sodii Salicylatis Fortis) (BP 1988, page 751)
      • 16.40 Ammonium Chloride Mixture BP (Mistura Ammonii Chloridi) (BP 1988, page 720)
      • 16.41 Kaolin Mixture BP (Mistura Kaolini) (BP 1988, page 738)
      • 16.42 Kaolin Mixture Paediatric BP (Mistura Kaolini pro Infantibus) (BP 1980, page 691)
      • 16.43 Belladonna and Ephedrine Mixture Paediatric BPC (Mistura Belladonnae et Ephedrinae pro Infantibus) (BPC 1973, page 737)
      • 16.44 Belladonna and Ipecacuanha Mixture Paediatric BPC (BPC 1973, page 738)
      • 16.45 Ammonium Chloride and Morphine Mixture BP (Mistura Tussi Sedativa) (BP 1988, page 720)
      • 16.46 Chalk with Opium Mixture Aromatic BPC (Mistura Cretae Aromatica cum Opio) (BPC 1973, page 739)
      • 16.47 Chloral Mixture BP (Mist Chloral) (BP 1988, page 725)
      • 16.48 Ferric Ammonium Citrate Mixture BPC (Mist Ferr et Ammon Cit) (BPC 1973, page 741)
      • 16.49 Ferric Ammonium Citrate Mixture Paediatric BPC (Mistura Ferri et Ammonii Citratis pro Infantibus) (BPC 1973, page 742)
      • 16.50 Ferrous Sulphate Mixture BPC (Mistura Ferri Sulphatis) (BPC 1973, page 742)
      • 16.51 Ipecacuanha and Morphine Mixture BPC (Mistura Tussi Nigra) (BPC 1973, page 745)
      • 16.52 Kaolin and Morphine Mixture BP (Mistura Kaolini Sedativa) (BP 1988, page 738)
      • 16.53 Magnesium Trisilicate and Belladonna Mixture BPC (Mist Mag Trisil et Bellad) (BPC 1973, page 747)
      • 16.54 Sodium Bicarbonate Paediatric Mixture BPC (Mist Sod Bicarb pro Inf) (BPC 1973, page 752)
      • 16.55 Chloral Elixir Paediatric BPC (Elixir Chloralis pro Infantibus) (BPC 1973, page 668)
      • 16.56 Codeine Linctus BPC (Linctus Codeinae) (BPC 1973, page 722)
      • 16.57 Codeine Linctus Paediatric BPC (BPC 1973, page 722)
      • 16.58 Diamorphine and Cocaine Elixir BPC (BPC 1973, page 669)
      • 16.59 Diamorphine, Cocaine and Chlorpromazine Elixir BPC (BPC 1973, page 669)
      • 16.60 Morphine and Cocaine Elixir BPC (BPC 1973, page 669)
      • 16.61 Ephedrine Elixir BPC (Elixir Ephedrinae) (BPC 1973, page 671)
      • 16.62 Paracetamol Elixir Paediatric BPC (Elixir Paracetamolis pro Infantibus) (BPC 1973, page 674)
      • 16.63 Isoniazid Elixir BPC (BPC 1973, page 672)
      • 16.64 Phenobarbitone Elixir BPC (Elixir Phenobarbitoni) (BPC 1973, page 675)
      • 16.65 Diamorphine Linctus BPC (Linctus Diamorphinae) (BPC 1973, page 723)
      • 16.66 Methadone Linctus BPC (Linctus Methadoni) (BPC 1973, page 723)
      • 16.67 Pholcodine Linctus Strong BPC (Linctus Pholcodinae Fortis) (BPC 1973, page 724)
      • 16.68 Pholcodine Linctus BPC (Linctus Pholcodinae) (BPC 1973, page 724)
      • 16.69 Simple Linctus BPC (Linctus Simplex) (BPC 1973, page 724)
      • 16.70 Simple Linctus Paediatric BPC (Linctus Simplex pro Infantibus) (BPC 1973, page 725)
      • 16.71 Linctus Squill Opiate BPC (also known as Gees Linctus) (Linctus Scillae Opiatus) (BPC 1973, page 725)
      • 16.72 Squill Linctus Opiate Paediatric BPC (Linctus Scillae Opiatus pro Infantibus) (BPC 1973, page 725)
      • 16.73 Compound Tolu Linctus Paediatric BPC (Linctus Tolutanus Compositus pro Infantibus) (BPC 1973, page 725)

      Liniments, lotions and applications

      • 17.1 Benzyl Benzoate Application BP (Benzyl Benz Applic) (BP 1988, page 621)
      • 17.2 Soap Liniment BPC (Linimentum Saponis, also known as Opodeldoc) (BPC 1973, page 726)
      • 17.3 Calamine Lotion BP (Calam Lot) (BP 1988, page 702)
      • 17.4 Salicylic Acid Lotion BP (Lotio Acidi Salicylici) (BP 1988, page 702)
      • 17.5 Sulphur Lotion Compound BPC (Lotio Sulph Co) (BPC 1973, page 729)
      • 17.6 Copper and Zinc Sulphates Lotion BPC (Dalibour Water) (BPC 1973, page 727)
      • 17.7 Zinc Sulphate Lotion BP (Lotio Rubra) (BP 1988, page 703)
      • 17.8 Calamine Lotion Oily BP (Lotio Calamine Oleosa) (BP 1980, page 682)
      • 17.9 White Liniment BPC (Linimentum Album) (BPC 1973, page 726)
      • 17.10 Compound Calamine Application BPC (Applicatio Calaminae Composita) (BPC 1973, page 648)

      Ointments and pastes

      • 18.1 Compound Benzoic Acid Ointment BP (Whitfield’s Ointment) (BP 1988, page 705)
      • 18.2 Calamine Ointment BP (Unguentum Calaminae) (BP 1988, page 706)
      • 18.3 Cetomacrogol Emulsifying Ointment BP, also called Non-ionic Emulsifying Ointment BP (Unguentum Cetomacrogolis Emulsificans) (BP 1988, page 706)
      • 18.4 Calamine and Coal Tar Ointment BP, also known as Compound Calamine Ointment BP (Unguentum Calaminae et Picis Carbonis) (BP 1988, page 706)
      • 18.5 Zinc and Salicylic Acid Paste BP (Lassar’s Paste) (BP 1988, page 868)
      • 18.6 Zinc and Coal Tar Paste BP (White’s Tar Paste) (BP 1988, page 868)
      • 18.7 Simple Ointment BP (Ung Simp) (BP 1988, page 713)
      • 18.8 Sulphur Ointment BP (BP 1980, page 701)
      • 18.9 Methyl Salicylate Ointment BP (Unguentum Methylis Salicylatis) (BP 1988, page 712)
      • 18.10 Zinc Ointment BP (Ung Zinc) (BP 1988, page 715)
      • 18.11 Cetrimide Emulsifying Ointment BP (Unguentum Cetrimidi Emulsificans) (BP 1988, page 707)
      • 18.12 Compound Zinc Paste BP (Co Zinc Paste) (BP 1988, page 868)
      • 18.13 Salicylic Acid Ointment BP (Ung Acid Salicyl) (BP 1988, page 713)
      • 18.14 Salicylic Acid and Sulphur Ointment BPC (Ung Acid Salicyl et Sulph) (BPC 1973, page 763)
      • 18.15 Coal Tar Paste BPC (Pasta Picis Carbonis) (BPC 1973, page 767)
      • 18.16 Emulsifying Ointment BP (Ung Emulsif) (BP 1988, page 707)
      • 18.17 Ichthammol Ointment BP (Unguentum Ichthammolis) (BP 1980, page 700)

      Powders

      • 19.1 Effervescent Powder Compound BPC (Pulvis Effervescens Compositus, also known as Seidlitz Powder) (BPC 1973, page 776)
      • 19.2 Compound Sodium Chloride and Dextrose Oral Powder BP (per powder) (BP 1980, page 710)
      • 19.3 Oral Rehydration Salts Formula A BP (BP 1988, page 874)
      • 19.4 Magnesium Trisilicate Powder Compound BP (Pulvis Magnesii Trisilicatis Compositus) (BP 1988, page 873)

      Miscellaneous formulae

      • 20.1 Ephedrine Nasal Drops BPC (Naristillae Ephedrinae) (BPC 1973, page 757)
      • 20.2 Sodium Bicarbonate Ear Drops BP (Auristillae Sodii Bicarbonatis) (BP 1988, page 670)
      • 20.3 Compound Sodium Chloride Mouthwash BP (Collutorium Sodii Chloridi Compositum) (BP 1988, page 703)
      • 20.4 Menthol and Eucalyptus Inhalation BP (Vapor Mentholis et Eucalypti) (BP 1980, page 577)
      • 20.5 Zinc Sulphate and Zinc Chloride Mouthwash BPC (Collutorium Zinci Sulphatis et Zinci Chloridi) (BPC 1973, page 756)
      • 20.6 Chloroxylenol Solution BP (Liquor Chloroxylenolis) (BP 1988, page 879)

    Appendix 1 Glossary of terms used in formulations

    Appendix 2 Abbreviations commonly used in pharmacy

    Appendix 3 Changing substance names from British Approved Names to recommended International Non-Proprietary Names

    Bibliography