SCHIFF'S DISEASES OF THE LIVER This title has been archived.
Author: Eugene Schiff, MD, FACP, FRCP, MACG, Michael Sorrell, MD, FACP, Willis Maddrey, MD, MACP, FRCP
Publisher: Lippincott Williams & Wilkins
Publication Date: 2007
Publisher: Lippincott Williams & Wilkins
Publication Date: 2007
ISBN 10: 0781760402
ISBN 13: 9780781760409
Edition: 10th
ISBN 13: 9780781760409
Edition: 10th
Description:
The premier clinical hepatology reference for 50 years, Schiff's Diseases of the Liver is in its Tenth Edition-now in full color throughout. This edition features a major new transplant section focusing on pre-transplant and post-transplant evaluation and management. Also included are updates on key topics such as hepatitis, NASH, and drug-induced pathologies. The first third of the book covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs. Subsequent sections address specific diseases and clinical syndromes. Each of the 12 sections begins with an overview, and each chapter starts with an outline of key concepts. Numerous clinical algorithms appear throughout the text.
Table of Contents
Front Matter
SECTION I Overview: Clinical Fundamentals of Hepatology
- KEY CONCEPTS
- Tests of Capacity of Liver to Transport Organic Anions and to Metabolize Drugs
- Tests for Detection of Injury to Hepatocytes (Serum Enzyme Tests)
- Tests of the Biosynthetic Capacity of the Liver
- Tests Used to Detect Fibrosis in the Liver
- Tests Used to Detect Chronic Inflammation or Fibrosis in the Liver or Altered Immunoregulation
- Use of Liver Function Tests
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Angiography
- Percutaneous Transhepatic Cholangiography
- Liver Biopsy
- Angioplasty and Stenting
- Transjugular Intrahepatic Portosystemic Shunt
- Thrombolytic Therapy
- Embolotherapy
- Percutaneous Needle-Directed Tumor Ablation
- Percutaneous Abscess Drainage
- Percutaneous Cholecystostomy
- Conclusion
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Indications and Contraindications
- Techniques
- Complications
- Benign or Premalignant Biliary Obstruction
- Hepatobiliary Surgery and Complications
- Other Benign Biliary Strictures and Injuries
- Malignant Biliary Obstruction
- Other Biliary Disease Infections
- Pediatric Endoscopic Retrograde Cholangiopancreatography
- REFERENCES
History Taking and Physical Examination for the Patient with Liver Disease
Laboratory Tests
Liver Biopsy and Laparoscopy
Imaging
Interventional Radiology Procedures for Diagnosis and Treatment of Hepatobiliary Disease
Endoscopic Retrograde Cholangiopancreatography
SECTION II General Considerations
- KEY CONCEPTS
- Sources, Structure, and Plasma Transport of Bilirubin
- Hepatic Disposition of Bilirubin
- Fate of Bilirubin in the Gastrointestinal Tract
- Bilirubin in the Urine
- Clinical Physiology of Bilirubin
- Measurement of Plasma Bilirubin Concentration
- Hyperbilirubinemia and Jaundice
- Familial Hyperbilirubinemias
- Familial Cholestasis Syndromes
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Red Blood Cell Abnormalities Caused by Liver Disease
- Liver Disease Caused by Red Blood Cell Abnormalities
- Myeloproliferative Disorders and the Liver
- Paroxysmal Nocturnal Hemoglobinuria and Hepatic Vascular Complications
- Thrombocytopenia in Liver Disease
- Hemolysis with Microangiopathic Blood Smear, Elevated Liver Enzymes, and Low Platelets in Pregnancy
- Decreased Synthesis of Coagulation Factors
- Functional Deficiencies of Coagulation Factors
- Consumptive Coagulopathy
- ANNOTATED REFERENCES
- REFERENCES
Physioanatomic Considerations
Bilirubin Metabolism and Jaundice
Hepatic Histopathology
Mechanisms of Liver Injury
The Liver in Systemic Disease
Hematologic Disorders and the Liver
Nutrition and the Liver
SECTION III Consequences of Liver Disease
- KEY CONCEPTS
- Etiology of Portal Hypertension
- Pathophysiology of Portal Hypertension
- Pathophysiology of Variceal Hemorrhage
- Assessment of Hepatic Hemodynamics in Patients with Cirrhosis
- Clinical Consequences of Portal Hypertension
- Pathophysiologic Basis of Therapy
- ACKNOWLEDGMENTS
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Etiology and Related Clinical Implications
- Spectrum of Liver Damage
- Mechanisms Impacting Hepatocellular Regeneration
- Pathophysiology of the Resultant Clinical Syndrome
- Supportive Management
- Selection Criteria for Liver Transplantation
- Auxiliary Partial Transplantation
- Extracorporeal Liver Support
- Hepatocyte and Stem Cell Transplantation
- ANNOTATED REFERENCES
- REFERENCES
Hepatic Fibrosis
Portal Hypertension and Nonsurgical Management
Surgical Management of Portal Hypertension
Renal Complications and Hepatorenal Syndrome
Pulmonary Manifestations of Liver Disease
Ascites and Spontaneous Bacterial Peritonitis
Hepatic Encephalopathy
Fulminant Hepatic Failure
SECTION IV Cholestatic Disorders
- KEY CONCEPTS
- Evaluation of Preoperative Risk Factors for Jaundice
- Causes of Postoperative Jaundice
- Postoperative Jaundice due to Biliary Obstruction
- Postoperative Intrahepatic Cholestasis
- Benign Postoperative Cholestasis
- Hepatic Ischemia
- Postoperative Jaundice due to Increased Bilirubin Load
- Postoperative Jaundice Associated with Parenteral Nutrition
- Postoperative Jaundice following Liver Transplantation
- ANNOTATED REFERENCES
- REFERENCES
Gallstone Disease: Pathogenesis and Treatment
Primary Sclerosing Cholangitis
Primary Biliary Cirrhosis
Postoperative Jaundice
SECTION V Viral Hepatitis
- KEY CONCEPTS
- History and Definition
- Epidemiology
- Pathophysiology
- Clinical Presentation of Autoimmune Hepatitis
- Diagnosis
- Natural Course and Prognosis
- Treatment Indications
- Induction of Remission
- Maintenance of Remission
- Failure of Remission
- Alternative Treatment Strategies
- Liver Transplantation
- Future Directions and Conclusions
- ANNOTATED REFERENCES
- REFERENCES
The Hepatitis Viruses
Hepatitis A
Hepatitis E
Hepatitis B and D
Hepatitis C
Autoimmune Hepatitis
SECTION VI Alcohol and Drug-Induced Disease
- KEY CONCEPTS
- Introduction
- Epidemiology and Risk Factors
- Toward Better Outcomes
- Diagnosis of Drug-Induced Liver Disease
- Clinicopathologic Syndromes of Drug-Induced Liver Disease
- Role of Drugs in Multifactorial Liver Disease
- Liver Disease Associated with Particular Classes of Drugs
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Mechanisms of Predictable Hepatotoxicity
- Enzymes Involved in Generating Reactive Metabolites
- Enzymes Involved in the Safe Elimination of Reactive Metabolites
- How the Reactive Metabolites Cause Hepatotoxicity
- Progression versus Recovery
- Variation in Susceptibility to Drug-Induced Liver Injury
- Relevance of Predictable Toxicity to Idiosyncratic Toxicity
- Hepatotoxicity Not Related to Reactive Metabolites
- The Pharmaceutical Industry and Preclinical Drug Testing
- Summary and Future Directions
- ANNOTATED REFERENCES
- REFERENCES
Alcoholic Liver Disease
Drug-Induced Liver Disease
Mechanisms of Drug-Induced Liver Injury
SECTION VII Genetics and Metabolic Disease
- KEY CONCEPTS
- History
- Classification of Iron Overload Syndromes
- HFE -Related Hereditary Hemochromatosis
- Non–HFE-Related Hereditary Hemochromatosis
- Clinical Features of Hereditary Hemochromatosis
- Diagnosis of Hereditary Hemochromatosis
- Treatment of Hereditary Hemochromatosis
- Family and Population Screening for Hereditary Hemochromatosis
- Analysis of HFE Mutations in Patients with Liver Disease
- Other Iron Storage Disorders
- Summary
- ACKNOWLEDGMENTS
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Incidence
- Liver Disease: Clinical Manifestations
- Lung Disease: Clinical Manifestations
- α 1 -Antitrypsin Structure, Function, and Physiology
- Pathogenesis of Liver Injury in PIZZ Individuals
- Mechanism for Deficiency of α 1 -Antitrypsin in PIZZ Individuals
- Mechanism of Liver Injury
- Diagnosis
- Treatment
- Genetic Counseling
- Population Screening
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Clinical and Histologic Criteria and Terminology
- Historic Perspective
- Epidemiology and Prevalence in High-Risk Groups
- Genetic Factors in Nonalcoholic Fatty Liver Disease
- Clinical and Laboratory Findings
- Imaging in Nonalcoholic Fatty Liver Disease: Ultrasonography, Computed Tomography Scan, Magnetic Resonance Imaging, and Magnetic Resonance Proton Spectroscopy
- The Use of Liver Biopsy in Nonalcoholic Fatty Liver Disease
- NATURAL HISTORY AND PROGNOSIS
- Experimental and Animal Models of Nonalcoholic Fatty Liver Disease
- Pathogenesis of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
- Other Conditions Associated with Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis — ‘‘Secondary’’ Nonalcoholic Steatohepatitis
- Managing the Obese Patient with Diabetes and Cirrhosis
- Treatment of Nonalcoholic Fatty Liver Disease
- ANNOTATED REFERENCES
- REFERENCES
Wilson Disease
Hemochromatosis and Iron Storage Disorders
α 1 -Antitrypsin Deficiency
Porphyrias
NONALCOHOLIC FATTY LIVER DISEASE
SECTION VIII Vascular Diseases of the Liver
SECTION IX Benign and Malignant Tumors: Cystic Disorders
- KEY CONCEPTS
- Focal Nodular Hyperplasia
- Hemangioma
- Hepatocellular Adenoma
- Macroregenerative Nodules
- Benign Focal Lesions of Bile Duct Origin
- Other Benign Mesenchymal Tumors
- Benign Lipomatous Tumors and Tumor-like Lesions
- Inflammatory Pseudotumor
- Clinical Approach to a Focal Solid Lesion of the Liver
- ANNOTATED REFERENCES
- REFERENCES
Benign Solid Tumors
Nodular and Cystic Lesions
Hepatocellular Carcinoma
Surgical Options for the Treatment of Hepatocellular Carcinoma
SECTION X The Liver in Pregnancy and Childhood
- KEY CONCEPTS
- Embryology of the Hepatobiliary System
- Development of Hepatobiliary Function
- Congenital Abnormalities in Hepatobiliary Structure
- Genetic/Metabolic Liver Disease
- Viral Hepatitis
- Liver Disease Associated with Parenteral Nutrition
- Autoimmune Hepatobiliary Disease
- Acquired Disorders of the Biliary Tract
- The Syndrome of Neonatal Hepatitis
- Tumors of the Hepatobiliary System in Children
- The Liver in Cystic Fibrosis
- Nonalcoholic Fatty Liver Disease
- Approach to Pediatric Patients with Hepatobiliary Signs or Symptoms
- Liver Transplantation in Children
- ANNOTATED REFERENCES
- REFERENCES
The Liver in Pregnancy
Liver Disease in Infancy and Childhood
SECTION XI Infectious and Granulomatous Disease
- KEY CONCEPTS
- Hepatitis B Virus
- Hepatitis D Virus
- Hepatitis A, E, and G Virus
- Hepatitis C Virus
- Hepatotoxicity Associated with Antiretroviral Therapy
- Steatosis and Lipodystrophy in Human Immunodeficiency Virus–Infected Patients
- Liver Infections in Human Immunodeficiency Virus–Infected Patients with Severe Immunosuppression
- Infections of Biliary Tract
- Hepatic Mass Lesions in Human Immunodeficiency Virus
- Liver Transplantation in Human Immunodeficiency Virus
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Pathophysiology of Granulomas
- Etiology of Granulomas
- Clinical Consequences of Hepatic Granulomas
- Clinical Evaluation of Hepatic Granulomas
- Specific Causes of Hepatic Granulomas
- Treatment of Hepatic Granulomas and Granulomatous Hepatitis: General Principles
- Summary
- ANNOTATED REFERENCES
- REFERENCES
Liver Abscesses
Parasitic Diseases
Bacterial and Systemic Infections
Hepatobiliary Manifestations of Human Immunodeficiency Virus
Granulomas of the Liver
SECTION XII Elements of Liver Transplantation
- KEY CONCEPTS
- Overview of the Immune Response and General Features of Immunosuppression
- Overview of Immunosuppressive Agents
- Corticosteroids
- Azathioprine
- Cyclosporine
- Tacrolimus
- Mycophenolate Mofetil
- Rapamycin
- Antibody Therapies
- Newer Immunosuppressive Agents
- Goals of Immunosuppression
- Conclusion
- ANNOTATED REFERENCES
- REFERENCES
- KEY CONCEPTS
- Cadaveric Donor Hepatectomy
- Donor after Cardiac Death
- Liver Transplantation—Recipient Procedure
- Alternatives to Standard Cadaveric Liver Transplantation—Historical Perspective
- Donor Selection
- Donor Safety
- Technique for Procurement of the Living Donor Right Lobe Graft
- Ongoing Controversies
- Hepatic Venous Drainage
- Biliary Reconstruction
- Recipient Results
- Donor Complications after Liver Donation/Resection
- Recipient Morbidity after Living Donor Right Lobe Transplantation
- Overview
- ANNOTATED REFERENCES
- REFERENCES
Selection and Timing of Liver Transplantation
Immunosuppression: The Global Picture
The First 6 Months Following Liver Transplantation
The Long-Term Care of Transplanted Patient
The Surgical Options of Liver Transplantation
Recurrent Disease Following Liver Transplantation
The Role of Retransplantation
Hepatobiliary Complications of Hematopoietic Cell Transplantation
Topics within this title:
- Abnormalities
- Antibody
- Ascites
- Carcinoma
- Cholestasis
- Cysts
- Diabetes
- Diabetes Mellitus
- Fatty Liver
- Fibrosis
- Gallstones
- Hemoglobinuria
- Hemorrhage
- Hepatitis
- Hepatitis A
- Hepatitis B
- Hepatitis B virus
- Hepatitis C
- Hepatitis E
- Hepatopulmonary Syndrome
- Hepatorenal Syndrome
- Hypertension
- Hypervitaminosis A
- Hyponatremia
- Infarction
- Liver Disease
- Liver Diseases
- Parasitic Diseases
- Peritonitis
- Schistosomiasis
- Syndrome
- Thrombosis
- Tick-Borne Diseases
- Virus