CASARETT AND DOULL'S TOXICOLOGY: THE BASIC SCIENCE OF POISONS The Basic Science of Poisons
Author: Curtis Klaassen, Ph.D.
Publisher: McGraw-Hill
Publication Date: 2008
Publisher: McGraw-Hill
Publication Date: 2008
ISBN 10: 0071470514
ISBN 13: 9780071470513
Edition: 7th
ISBN 13: 9780071470513
Edition: 7th
Description:
Long established as the gold standard in the field, Casarett & Doull's Toxicology equips you with an unsurpassed understanding of modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline. The new edition features many new contributors, new content on chemical terrorism, and is updated throughout.
Table of Contents
Front Matter
UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY
UNIT 2 DISPOSITION OF TOXICANTS
UNIT 3 NON-ORGAN-DIRECTED TOXICITY
- WHAT IS GENETIC TOXICOLOGY?
- HISTORY OF GENETIC TOXICOLOGY
- HEALTH IMPACT OF GENETIC ALTERATIONS
- CANCER AND GENETIC RISK ASSESSMENTS
- MECHANISMS OF INDUCTION OF GENETIC ALTERATIONS
- ASSAYS FOR DETECTING GENETIC ALTERATIONS
- HUMAN POPULATION MONITORING
- NEW APPROACHES FOR GENETIC TOXICOLOGY
- CONCLUSIONS
- ACKNOWLEDGMENTS
- REFERENCES
- HISTORY
- SCOPE OF PROBLEM: THE HUMAN EXPERIENCE
- PRINCIPLES OF DEVELOPMENTAL TOXICOLOGY
- MECHANISMS AND PATHOGENESIS OF DEVELOPMENTAL TOXICITY
- PHARMACOKINETICS AND METABOLISM IN PREGNANCY
- RELATIONSHIPS BETWEEN MATERNAL AND DEVELOPMENTAL TOXICITY
- MATERNAL FACTORS AFFECTING DEVELOPMENT
- DEVELOPMENTAL TOXICITY OF ENDOCRINE-DISRUPTING CHEMICALS
- MODERN SAFETY ASSESSMENT
- PATHWAYS TO THE FUTURE
- REFERENCES
CHEMICAL CARCINOGENESIS
GENETIC TOXICOLOGY
DEVELOPMENTAL TOXICOLOGY
UNIT 4 TARGET ORGAN TOXICITY
- INTRODUCTION TO OCULAR AND VISUAL SYSTEM TOXICOLOGY
- EXPOSURE TO THE EYE AND VISUAL SYSTEM
- TESTING VISUAL FUNCTION
- TARGET SITES AND MECHANISMS OF ACTION: CORNEA
- TARGET SITES AND MECHANISMS OF ACTION: LENS
- TARGET SITES AND MECHANISMS OF ACTION: RETINA
- TARGET SITES AND MECHANISMS OF ACTION: OPTIC NERVE AND TRACT
- TARGET SITES AND MECHANISMS OF ACTION: THE CENTRAL VISUAL SYSTEM
- ACKNOWLEDGEMENTS
- REFERENCES
- INTRODUCTION
- THE REPRODUCTIVE CYCLE
- REPRODUCTIVE DEVELOPMENT AND SEXUAL DIFFERENTIATION
- GAMETOGENESIS
- NEONATAL DEVELOPMENT
- INFANTILE DEVELOPMENT
- PUBERTAL DEVELOPMENT
- SEXUAL MATURITY
- TESTICULAR STRUCTURE AND FUNCTION
- MATING BEHAVIOR IN THE RAT
- FERTILIZATION
- IMPLANTATION
- PLACENTA
- PREGNANCY
- PARTURITION
- LACTATION
- SENESCENCE
- ENDOCRINE DISRUPTION (INCLUDING SCREENING AND PUBERTY)
- TESTING FOR REPRODUCTIVE TOXICITY
- EVALUATION OF TOXICITY TO REPRODUCTION
- REFERENCES
TOXIC RESPONSES OF THE BLOOD
TOXIC RESPONSES OF THE IMMUNE SYSTEM
TOXIC RESPONSES OF THE LIVER
TOXIC RESPONSES OF THE KIDNEY
TOXIC RESPONSES OF THE RESPIRATORY SYSTEM
TOXIC RESPONSES OF THE NERVOUS SYSTEM
TOXIC RESPONSES OF THE OCULAR AND VISUAL SYSTEM
TOXIC RESPONSES OF THE HEART AND VASCULAR SYSTEM
TOXIC RESPONSES OF THE SKIN
TOXIC RESPONSES OF THE REPRODUCTIVE SYSTEM
TOXIC RESPONSES OF THE ENDOCRINE SYSTEM
UNIT 5 TOXIC AGENTS
- INTRODUCTION
- BASIC RADIATION CONCEPTS
- INTERACTION OF RADIATION WITH MATTER
- ABSORBED DOSE
- MECHANISMS OF DNA DAMAGE AND MUTAGENESIS
- HUMAN STUDIES OF RADIATION TOXICITY
- LIFETIME DOMESTIC LUNG CANCER RISK PROJECTIONS FOR RADON EXPOSURE
- DOMESTIC EPIDEMIOLOGY
- NATURAL RADIOACTIVITY AND RADIATION BACKGROUND
- LOCAL ENVIRONMENTAL RELEASES
- SUMMARY OF HUMAN CANCER RISKS FROM RADIATION
- REFERENCES
TOXIC EFFECTS OF PESTICIDES
TOXIC EFFECTS OF METALS
TOXIC EFFECTS OF SOLVENTS AND VAPORS
HEALTH EFFECTS OF RADIATION AND RADIOACTIVE MATERIALS
PROPERTIES AND TOXICITIES OF ANIMAL VENOMS
TOXIC EFFECTS OF PLANTS
UNIT 6 ENVIRONMENTAL TOXICOLOGY
UNIT 7 APPLICATIONS OF TOXICOLOGY
- ANALYTIC TOXICOLOGY
- ANALYTIC ROLE IN GENERAL TOXICOLOGY
- ANALYTIC ROLE IN FORENSIC TOXICOLOGY
- TOXICOLOGIC INVESTIGATION OF A POISON DEATH
- CRIMINAL POISONING OF THE LIVING
- FORENSIC URINE DRUG TESTING
- HUMAN PERFORMANCE TESTING
- COURTROOM TESTIMONY
- ANALYTIC ROLE IN CLINICAL TOXICOLOGY
- ANALYTIC ROLE IN THERAPEUTIC MONITORING
- ANALYTIC ROLE IN BIOLOGICAL MONITORING
- SUMMARY
- REFERENCES
FOOD TOXICOLOGY
ANALYTIC/FORENSIC TOXICOLOGY
CLINICAL TOXICOLOGY
OCCUPATIONAL TOXICOLOGY
COLOR INSERT
Topics within this title:
- Allergic Contact Dermatitis
- Allergy
- Ankylosing Spondylitis
- Antigen
- Cancer
- Contact dermatitis
- Dermatitis
- duration
- Food Allergy
- Hyperplasia
- Immune system
- Lipidosis
- Occupational Diseases
- Poisoning
- Ringworm
- Signs and Symptoms
- Spondylitis
- Syndromes
- Tinea
- Tinea Capitis
- Toxicities
- Toxicity
- Tumor
- Tumors
- Urticaria