GOODMAN & GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS This title has been archived.
Author: Laurence Brunton, PhD, John Lazo, PhD, Keith Parker, MD, PhD
Publisher: McGraw-Hill
Publication Date: 2006
Publisher: McGraw-Hill
Publication Date: 2006
ISBN 10: 0071422803
ISBN 13: 9780071422802
Edition: 11th
ISBN 13: 9780071422802
Edition: 11th
Description:
The undisputed leader in medical pharmacology, without equal. Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the "desert island" book of all medical pharmacology-if you can own just one pharmacology book, this is it.
Table of Contents
Front Matter
SECTION I: General Principles
- Introduction
- I. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination: Physicochemical Factors in Transfer of Drugs Across Membranes
- Drug Absorption, Bioavailability, and Routes of Administration
- Distribution of Drugs
- Excretion of Drugs
- Metabolism of Drugs
- Clinical Pharmacokinetics
- Distribution
- II. Pharmacodynamics: Mechanisms of Drug Action and the Relationship between Drug Concentration and Effect
- Quantitation of Drug–Receptor Interactions and Effects
- Bibliography
- Introduction
- Membrane Transporters in Therapeutic Drug Responses
- Membrane Transporters and Adverse Drug Responses
- Basic Mechanisms of Membrane Transport
- Kinetics of Transport
- Vectorial Transport
- Molecular Structures of Transporters
- Transporter Superfamilies in the Human Genome
- Genetic Variation in Membrane Transporters: Implications for Clinical Drug Response
- Transporters Involved in Pharmacokinetics
- Transporters Involved in Pharmacodynamics: Drug Action in the Brain
- Blood–Brain Barrier and Blood–CSF Barrier
- Bibliography
- How Humans Cope with Exposure to Xenobiotics
- The Phases of Drug Metabolism
- Sites of Drug Metabolism
- The CYPs
- Drug-Drug Interactions
- Flavin-Containing Monooxygenases (FMOs)
- Hydrolytic Enzymes
- Conjugating Enzymes
- Glucuronidation
- Sulfation
- Glutathione Conjugation
- N-Acetylation
- Methylation
- The Role of Xenobiotic Metabolism in the Safe and Effective Use of Drugs
- Induction of Drug Metabolism
- Role of Drug Metabolism in the Drug Development Process
- Bibliography
- Introduction
- Evaluation of the Evidence
- Patient-Centered Therapeutics
- Determinants of Interindividual Variation in Response to Drugs
- Interactions between Drugs
- Genetic Determinants of the Response to Drugs
- The Pharmacodynamic Characteristics of a Drug That Determine Its Use in Therapy
- Adverse Drug Reactions and Drug Toxicity
- Therapeutic Drug Monitoring
- The Dynamic Information Base
- Drug Nomenclature
- Drug Development and Its Regulation
- Bibliography
Pharmacokinetics and Pharmacodynamics
Membrane Transporters and Drug Response
Drug Metabolism
Pharmacogenetics
The Science of Drug Therapy
SECTION II: Drugs Acting at Synaptic and Neuroeffector Junctional Sites
- Acetylcholine and Its Muscarinic Receptor Target
- Cholinomimetic Choline Esters and Natural Alkaloids
- Muscarinic Receptor Antagonists
- Therapeutic Uses of Muscarinic Receptor Antagonists
- Poisoning by Muscarinic Receptor Antagonists and Other Drugs with Anticholinergic Properties
- Clinical Summary
- Bibliography
- I. Catecholamines and Sympathomimetic Drugs
- Classification of Sympathomimetic Drugs
- Endogenous Catecholamines
- β Adrenergic Receptor Agonists
- α1-Selective Adrenergic Receptor Agonists
- α2-Selective Adrenergic Receptor Agonists
- Miscellaneous Sympathomimetic Agonists
- Therapeutic Uses of Sympathomimetic Drugs
- II. Adrenergic Receptor Antagonists
- α Adrenergic Receptor Antagonists
- β Adrenergic Receptor Antagonists
- Non-Subtype-Selective β Adrenergic Receptor Antagonists
- β1-Selective Adrenergic Receptor Antagonists
- Adverse Effects and Precautions
- Therapeutic Uses
- Bibliography
Neurotransmission
Muscarinic Receptor Agonists and Antagonists
Anticholinesterase Agents
Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
Adrenergic Agonists and Antagonists
5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists
SECTION III: Drugs Acting on the Central Nervous System
- Introduction
- Terminology and Epileptic Seizure Classification
- Nature and Mechanisms of Seizures and Antiseizure Drugs
- Antiseizure Drugs: General Considerations
- Hydantoins
- Antiseizure Barbiturates
- Iminostilbenes
- Succinimides
- Valproic Acid
- Benzodiazepines
- Other Antiseizure Drugs
- General Principles and Choice of Drugs for the Therapy of the Epilepsies
- Bibliography
- Overview
- Endogenous Opioid Peptides
- Opioid Receptors
- Effects of Clinically Used Opioids
- Morphine and Related Opioid Agonists
- Other μ Receptor Agonists
- Acute Opioid Toxicity
- Opioid Agonist/Antagonists and Partial Agonists
- Opioid Antagonists
- Centrally Active Antitussive Agents
- Therapeutic Uses of Opioid Analgesics
- Clinical Summary
- Bibliography
Neurotransmission and the Central Nervous System
General Anesthetics
Local Anesthetics
Therapeutic Gases
Hypnotics and Sedatives
Drug Therapy of Depression and Anxiety Disorders
Pharmacotherapy of Psychosis and Mania
Pharmacotherapy of the Epilepsies
Treatment of Central Nervous System Degenerative Disorders
Opioid Analgesics
Ethanol
Drug Addiction and Drug Abuse
SECTION IV: Autacoids: Drug Therapy of Inflammation
- Introduction
- NSAIDs: Nonsteroidal Antiinflammatory Drugs
- The Salicylates
- Para-Aminophenol Derivatives: Acetaminophen
- Acetic Acid Derivatives: Indomethacin, Sulindac, and Etodolac
- The Fenamates
- Tolmetin, Ketorolac, and Diclofenac
- Propionic Acid Derivatives
- Enolic Acids (Oxicams)
- Pyrazolon Derivatives
- Cyclcooxygenase-2 Selective NSAIDs
- Other Nonsteroidal Antiinflammatory Drugs
- Other Drugs for Rheumatoid Arthritis
- Gold
- Pharmacotherapy of Gout
- Uricosuric Agents
- Conclusion
- Bibliography
Histamine, Bradykinin, and Their Antagonists
Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
Analgesic-Antipyretic and Antiinflammatory Agents; Pharmacotherapy of Gout
Pharmacotherapy of Asthma
SECTION V: Drugs Affecting Renal and Cardiovascular Function
- Introduction
- Renal Anatomy and Physiology
- Principles of Diuretic Action
- Inhibitors of Carbonic Anhydrase
- Osmotic Diuretics
- Inhibitors of Na+–K+–2Cl– Symport (Loop Diuretics, High-Ceiling Diuretics)
- Inhibitors of Na+–Cl– Symport (Thiazide and Thiazide-like Diuretics)
- Inhibitors of Renal Epithelial Na+ Channels (K+-Sparing Diuretics)
- Antagonists of Mineralocorticoid Receptors (Aldosterone Antagonists, K+-Sparing Diuretics)
- Clinical Summary
- Bibliography
- Vasopressin and Other Agents Affecting the Renal Conservation of Water: Introduction
- Introduction to Vasopressin
- Physiology of Vasopressin
- Basic Pharmacology of Vasopressin
- Vasopressin Receptor Agonists and Antagonists
- Diseases Affecting the Vasopressin System
- Clinical Summary; Pharmacology of Vasopressin Peptides
- Bibliography
- Pathophysiology of Ischemic Heart Disease
- Organic Nitrates
- Ca2+ Channel Antagonists
- β Adrenergic Receptor Antagonists
- Comparison of Antianginal Therapeutic Strategies
- Antiplatelet, Anti-Integrin, and Antithrombotic Agents
- Treatment of Claudication and Peripheral Vascular Disease
- Mechanopharmacological Therapy: Drug-Eluting Endovascular Stents
- Bibliography
Diuretics
Vasopressin and Other Agents Affecting the Renal Conservation of Water
Renin and Angiotensin
Treatment of Myocardial Ischemia
Therapy of Hypertension
Pharmacotherapy of Congestive Heart Failure
Antiarrhythmic Drugs
Drug Therapy for Hypercholesterolemia and Dyslipidemia
SECTION VI: Drugs Affecting Gastrointestinal Function
- Introduction
- Physiology of Gastric Secretion
- Proton Pump Inhibitors
- H2-Receptor Antagonists
- Tolerance and Rebound with Acid-Suppressing Medications
- Agents That Enhance Mucosal Defense
- Sucralfate
- Antacids
- Other Acid Suppressants and Cytoprotectants
- Specific Acid-Peptic Disorders and Therapeutic Strategies
- Clinical Summary
- Bibliography
- Introduction
- Introduction to Gastrointestinal Motility
- Overview of Functional and Motility Disorders of the Bowel
- Prokinetic Agents and Other Stimulants of GI Contractility
- Laxatives, Cathartics, and Therapy for Constipation
- Antidiarrheal Agents
- Irritable Bowel Syndrome
- Antispasmodics and Other Agents
- Antinauseants and Antiemetic Agents
- Dronabinol
- Agents Used for Miscellaneous Gastrointestinal Disorders
- Bile Acids
- Antiflatulence Agents
- Clinical Summary
- Bibliography
Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
Treatment of Disorders of Bowel Motility and Water Flux; Antiemetics; Agents Used in Biliary and Pancreatic Disease
Pharmacotherapy of Inflammatory Bowel Disease
SECTION VII: Chemotherapy of Parasitic Infections
- Introduction
- Biology of Malarial Infection
- Classification of Antimalarial Agents
- Artemisinin and Derivatives
- Atovaquone
- Diaminopyrimidines
- Proguanil
- Quinolines and Related Compounds
- Sulfonamides and Sulfones
- Tetracyclines
- Principles and Guidelines for Prophylaxis and Chemotherapy of Malaria
- New Targets
- Clinical Summary
- Bibliography
Chemotherapy of Protozoal Infections
Chemotherapy of Protozoal Infections
Chemotherapy of Helminth Infections
SECTION VIII: Chemotherapy of Microbial Diseases
- Introduction
- I. Drugs for Tuberculosis: Isoniazid
- Rifampin and Other Rifamycins
- Ethambutol
- Streptomycin
- Pyrazinamide
- Quinolones
- Linezolid
- Interferon-γ
- Ethionamide
- Aminosalicylic Acid
- Cycloserine
- Other Drugs
- Chemotherapy of Tuberculosis
- II. Drugs for Mycobacterium avium Complex
- Rifabutin
- Macrolides
- Quinolones
- Chemotherapy of Mycobacterium avium Complex
- III. Drugs for Leprosy
- Clinical Summary
- Bibliography
- I. Overview of HIV Infection
- Pathogenesis of HIV-Related Disease
- History of Antiretroviral Therapy
- Principles of HIV Chemotherapy
- II. Drugs Used to Treat HIV Infection: Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
- Nonnucleoside Reverse Transcriptase Inhibitors
- HIV Protease Inhibitors
- Entry Inhibitors
- Current Treatment Guidelines; Clinical Summary
- Bibliography
General Principles of Antimicrobial Therapy
Sulfonamides, Trimethoprim–Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections
Penicillins, Cephalosporins, and Other β-Lactam Antibiotics
Aminoglycosides
Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents
Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy
Antimicrobial Agents: Antifungal Agents
Antiviral Agents (Nonretroviral)
Antiretroviral Agents and Treatment of HIV Infection
SECTION IX: Chemotherapy of Neoplastic Diseases
- Introduction
- I. Alkylating Agents
- Toxicities of Alkylating Agents
- Clinical Pharmacology
- Miscellaneous Alkylating Drugs
- Platinum Coordination Complexes
- II. Antimetabolites: Folic Acid Analogs
- Pyrimidine Analogs
- Cytidine Analogs
- Purine Analogs
- III. Natural Products: Antimitotic Drugs
- Camptothecin Analogs
- Antibiotics
- Epipodophyllotoxins
- Enzymes
- IV. Miscellaneous Agents: Hydroxyurea
- Differentiating Agents
- Protein Tyrosine Kinase Inhibitors
- Thalidomide
- Estramustine
- Biological Response Modifiers
- V. Hormones and Related Agents: Glucocorticoids
- Progestins
- Estrogens and Androgens
- Aromatase Inhibitors
- Anti-Androgen Therapy in Prostate Cancer
- Clinical Summary
- Bibliography
Antineoplastic Agents
SECTION X: Immunomodulators
SECTION XI: Drugs Acting on the Blood and the Blood-Forming Organs
- Introduction
- I. Hematopoietic Growth Factors
- Erythropoietins
- Myeloid Growth Factors
- Thrombopoietic Growth Factors
- II. Drugs Effective in Iron Deficiency and Other Hypochromic Anemias: Iron and Iron Salts
- Copper
- Pyridoxine
- Riboflavin
- III. Vitamin B12, Folic Acid, and the Treatment of Megaloblastic Anemias
- Vitamin B12
- Folic Acid
- Clinical Summary
- Bibliography
Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs
SECTION XII: Hormones and Hormone Antagonists
- Physiology of Mineral Homeostasis and Bone Metabolism
- Physiology of Calcium and Phosphate Regulation
- Bone Physiology
- Disorders of Mineral Homeostasis and Bone
- Specific Disorders of Bone
- Pharmacological Treatment of Disorders of Mineral Ion Homeostasis and Bone Metabolism
- Therapeutic Uses of Vitamin D
- Calcitonin
- Bisphosphonates
- Parathyroid Hormone (PTH)
- Calcium Sensor Mimetics: Cinacalcet
- Integrated Approach to Osteoporosis Prevention and Treatment
- Fluoride
- Clinical Summary
- Bibliography
Pituitary Hormones and Their Hypothalamic Releasing Hormones
Thyroid and Antithyroid Drugs
Estrogens and Progestins
Androgens
Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones
Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas
Agents Affecting Mineral Ion Homeostasis and Bone Turnover
SECTION XIII: Dermatology
- Dermatological Pharmacology: Introduction
- The Structure and Function of Skin
- Drug Delivery in Dermatological Diseases
- Glucocorticoids
- Retinoids
- Photochemotherapy
- Antihistamines
- Antimicrobial Agents
- Antimalarial Agents
- Cytotoxic and Immunosuppressant Drugs
- Miscellaneous Immunosuppressant and Antiinflammatory Agents
- Biological Agents
- Intravenous Immunoglobulin in Dermatology
- Sunscreens
- The Treatment of Pruritus
- Miscellaneous Drugs
- Drugs for Hyperkeratotic Disorders
- Drugs for Androgenetic Alopecia
- Treatment of Hyperpigmentation
- Miscellaneous Agents
- Bibliography
Dermatological Pharmacology
SECTION XIV: Ophthalmology
SECTION XV: Toxicology
Appendices
Topics within this title:
- Anemias
- Arrhythmias
- Arsenic Poisoning
- Asthma
- Atherosclerosis
- Blepharospasm
- Cadmium Poisoning
- Cancer
- Carcinoma
- Cardiovascular Diseases
- Congestive Heart Failure
- Constipation
- Cramps
- Cretinism
- Diabetes
- Diabetes Mellitus
- Diarrhea
- Drug Abuse
- Drug Addiction
- Drug Dependence
- duration
- Dyslipidemia
- Epilepsies
- Fever
- Fever of Unknown Origin
- Gastroesophageal Reflux
- Gastroesophageal Reflux Disease
- Glaucoma
- Gout
- Heart Disease
- Histamine
- HIV
- HIV Infection
- Hypercholesterolemia
- Hyperlipidemia
- Hyperpigmentation
- Hypertension
- Hypertriglyceridemia
- Hypochromic Anemias
- Hypoglycemia
- Hypoxia
- Infertility
- Inflammatory Bowel Disease
- Insomnia
- Intoxication
- Ischemia
- Ischemic Heart Disease
- Lateral Sclerosis
- Lead Poisoning
- Leprosy
- Malaria
- Mercury Poisoning
- Migraine
- Multiple Sclerosis
- Myasthenia Gravis
- Myocardial Ischemia
- Nausea
- Nocturnal Leg Cramps
- NSAIDs
- Osteomalacia
- Osteoporosis
- Overdose
- Pancreatic Disease
- Pancreatitis
- PDT
- Peptic Ulcer
- Peptic Ulcers
- Peripheral Vascular Disease
- Poisoning
- Prostate Cancer
- Pruritus
- Renal Osteodystrophy
- Sclerosis
- Steatorrhea
- Strabismus
- Syndrome
- Syndromes
- Thyroid Storm
- Toxicity
- Trauma
- Tuberculosis
- Ulcer
- Ulcers
- Urinary Tract Infections
- Vascular Disease
- Virus
- Vomiting